119162-53-7

Basic information

• Product Name: 3-(4-Bromo-phenyl)isoxazol-5-ylamine
• Synonyms: 5-Amino-3-(4-bromophenyl)isoxazole, 3-(4-Bromophenyl)-1,2-oxazol-5-amine
• CAS NO: 119162-53-7
• Molecular Formula: C₉H₇BrN₂O
• Molecular Weight: 239.08
• Mol File: 119162-53-7.mol

Chemical Properties

• Melting Point: 160-163°
• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-(4-Bromo-phenyl)isoxazol-5-ylamine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-Bromo-phenyl)isoxazol-5-ylamine(119162-53-7)
• EPA Substance Registry System: 3-(4-Bromo-phenyl)isoxazol-5-ylamine(119162-53-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 119162-53-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Development:
3-(4-Bromo-phenyl)isoxazol-5-ylamine is used as a key intermediate in the synthesis of pharmaceuticals for its potential biological activities. It is valued for its ability to contribute to the development of new drugs that can address unmet medical needs.
Used in Agrochemical Production:
In the agrochemical industry, 3-(4-Bromo-phenyl)isoxazol-5-ylamine is utilized as a precursor in the creation of compounds that can be used in crop protection and pest management, enhancing agricultural productivity and crop quality.
Used in Organic Synthesis:
3-(4-Bromo-phenyl)isoxazol-5-ylamine is employed as a versatile building block in organic synthesis, allowing for the construction of complex organic molecules with diverse applications in chemical research and industry.
Used in Specialty Chemicals:
3-(4-Bromo-phenyl)isoxazol-5-ylamine is also used in the development of specialty chemicals, where its unique properties can be harnessed to create high-value products for specific applications in various fields, such as materials science, coatings, and dyes.

Upstream product

• 151-50-8 potassium cyanide 
• 71426-51-2 anti-α,4'-dibromoacetophenone oxime 
• 4592-94-3 3-(4-bromophenyl)-3-oxopropanenitrile 

Downstream Products

• 334709-82-9 4-(4-bromophenyl)-1,2,5-thiadiazole-3-carboxamide 

Relevant articles and documents

Gramine-based structure optimization to enhance anti-gastric cancer activity

Gramine is a natural indole alkaloid with a wide range of biological activities, but its anti-gastric cancer activity is poor. Herein, a pharmacophore fusion strategy was adopted to design and synthesize a new series of indole-azole hybrids on the structural basis of gramine. Based on our previous studies, different nitrogen-containing five-membered heterocyclic rings and terminal alkyne group were introduced into the indole-based scaffold to investigate their effect on improving the anti-gastric cancer activity of gramine derivatives. Structure-activity relationship (SAR) studies highlighted the role played by terminal alkyne in enhancing the inhibitory effect, and compound 16h displayed the best antiproliferative activity against gastric cancer MGC803 cells with IC50 value of 3.74 μM. Further investigations displayed compound 16h could induce mitochondria-mediated apoptosis, and caused cell cycle arrest at G2/M phase. Besides, compound 16h could inhibit the metastasis ability of MGC803 cells. Our studies may provide a new strategy for structural optimization of gramine to enhance anti-gastric cancer activity, and provide a potential candidate for the treatment of gastric cancer.

An enantioselective aza-Friedel-Crafts reaction of 5-aminoisoxazoles with isatin-derived: N -Boc ketimines

By employing a chiral phosphoric acid as a catalyst, an enantioselective aza-Friedel-Crafts reaction of 5-aminoisoxazoles with isatin-derived N-Boc ketimines was realized. The reaction provided a wide variety of novel 3-isoxazole 3-amino-oxindoles with good yields (up to 99%) and moderate to good enantioselectivities (up to 99%). The absolute configuration of one product was assigned by X-ray crystal structural analysis and a plausible reaction mechanism was proposed. In addition, a scale-up reaction was performed successfully. Finally, one product was subjected to Suzuki-Miyaura coupling with phenylboronic acid to afford the product in a moderate yield without erosion of the enantioselectivity. This journal is

INHIBITING TRABID

The present disclosure is directed to compounds of formulas (I) - (VII), which are useful as modulators of TRABID. The compounds are further useful in the inhibition of TRABID and the treatment of diseases or disorders associated with the inhibition of TRABID. For instance, the disclosure is concerned with compounds and compositions for inhibition of TRABID, methods of treating diseases associated with the inhibition of TRABID (e.g., autoimmune inflammatory diseases including, but not limited to, psoriasis), and methods of synthesis of these compounds.

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A highly chemoselective reaction between 5-aminoisoxazoles and α-diazocarbonyl compounds has been described. Both Wolff rearrangement and N-H insertion products can be obtained selectively by the judicious choice of reaction conditions. In the case of the

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