HETEROARYL DIAMIDE COMPOUNDS USEFUL AS MMP-13 INHIBITORS
Disclosed are compounds and compositions of the formula (I) as described herein which are inhibitors of MMP-13. Also disclosed are methods of using and making compounds of the formula (I).
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Page/Page column 74-75
(2010/06/15)
Improving potency and selectivity of a new class of non-Zn-chelating MMP-13 inhibitors
Discovery and optimization of potency and selectivity of a non-Zn-chelating MMP-13 inhibitor with the aid of protein co-crystal structural information is reported. This inhibitor was observed to have a binding mode distinct from previously published MMP-1
Heim-Riether, Alexander,Taylor, Steven J.,Liang, Shuang,Gao, Donghong Amy,Xiong, Zhaoming,Michael August,Collins, Brandon K.,Farmer II, Bennett T.,Haverty, Kathleen,Hill-Drzewi, Melissa,Junker, Hans-Dieter,Mariana Margarit,Moss, Neil,Neumann, Thomas,Proudfoot, John R.,Keenan, Lana Smith,Sekul, Renate,Zhang, Qiang,Li, Jun,Farrow, Neil A.
scheme or table
p. 5321 - 5324
(2010/05/02)
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