- Deuterated pyrrolidone derivative Pharmaceutical compositions and uses thereof
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The invention relates to a deuterated pyrrolidone derivative and a preparation method thereof, and also relates to application of the deuterated pyrrolidone derivative and a pharmaceutical composition thereof in treatment and prevention of metabolic disorder related diseases, and belongs to the field of medicines.
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Paragraph 0065-0066; 0068
(2021/10/27)
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- Copper-catalyzed three-component reactions of phenols, acyl chlorides and Wittig reagents for the synthesis of β-aryloxyl acrylates
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The synthesis of aryloxyl acrylates has been achieved through a new three-component synthetic method involving the assembly of phenols, acyl chlorides and Wittig reagents in the presence of a copper catalyst using glucose as a green ligand. β-Aryloxyl acrylates have been prepared with high diversity and in good to excellent yields involving the cascade formation of a new CC bond and a C(sp2)-O bond.
- Zhang, Yi,Liu, Yunyun,Wan, Jie-Ping
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supporting information
p. 1567 - 1569
(2015/03/18)
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- Enantioselective synthesis of β-aryloxycarboxylic esters via asymmetric hydrogenation of β-aryloxy-α,β-unsaturated esters
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A novel synthesis of β-aryloxycarboxylic esters via asymmetric hydrogenation of the corresponding β-aryloxy-α,β-unsaturated esters has been demonstrated. Bis(norbornadiene)rhodium(I) tetrafluoroborate (1 mol %) and Walphos W008-1 were used to generate the
- Stewart, Gavin W.,Yamagata, Adam D. Gammack,Gibson, Andrew W.,Keen, Stephen P.,Scott, Jeremy P.,Shevlin, Michael
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supporting information
p. 5440 - 5443,4
(2012/12/12)
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- PYRROLIDINONE GLUCOKINASE ACTIVATORS
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Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of metabolic diseases and disorders such as, for example, type II diabetes mellitus.
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Page/Page column 58-59
(2009/10/30)
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