Reductive Deuteration of Aromatic Esters for the Synthesis of α,α-Dideuterio Benzyl Alcohols Using D 2O as Deuterium Source
α,α-Dideuterio benzyl alcohols are important building blocks for the synthesis of deuterium-labeled medicines and agrochemicals. We have developed the first general single-electron transfer reductive deuteration of readily commercially available aromatic
Luo, Shihui,Weng, Chaoqun,Ding, Yuxuan,Ling, Chen,Szostak, Michal,Ma, Xiaodong,An, Jie
supporting information
p. 51 - 56
(2020/11/10)
An α, α - dideuterium substituted benzyl alcohol compound. Deuterated drug and method for reducing deuteration of benzoate compound
The invention relates to a method. Α, α-deuterated benzyl alcohol compound and preparation thereofΑ, αThe method for reducing and deuteration - dideuterium-substituted benzyl alcohol compounds is characterized in that the benzoate compound represented by
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Paragraph 0033-0034
(2021/09/08)
Substituted morpholinyl compounds
This disclosure relates to novel substituted morpholinyl compounds and their derivatives, pharmaceutically acceptable salts, solvates, and hydrates thereof. This disclosure also provides compositions comprising a compound of this disclosure and the use of
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Page/Page column 10
(2008/12/04)
Side Chain Hydroxylation of Aromatic Compounds by Fungi. Part 4. Influence of the para Substituent on Kinetic Isotope Effects During Benzylic Hydroxylation by Mortierella isabellina
The benzylic hydroxylation of a series of para-substituted toluenes by the fungus Mortierella isabellina has been studied by using CD3, CHD2, and CH2D methyl labelled substrates.Inter- and intramolecular primary and secondary deuterium kinetic isotope effect ratios have been determined: the intermolecular primary effects are maximal with strongly electron-withdrawing para substituents (R = CN and CF3), while the intramolecular primary effects are minimal for R = H but increase in instances where R is electron donating or withdrawing.These results are interpreted in terms of a dependence of the hydroxylation mechanism on the nature of the para substituent.
Holland, Herbert L.,Brown, Frances M.,Conn, Morgan
p. 1651 - 1655
(2007/10/02)
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