- The synthesis of substituted phenols from pyranone precursors
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The syntheses of various substituted phenols from pyranone precursors, namely 4H-pyran-4-one, 3-(benzyloxy)-2-methyl-4H-pyran-4-one (benzyl-maltol), 2,6-dimethyl-4H-pyran-4-one and diethyl 4-oxo-4H-pyran-2,6-dicarboxylate (diethyl chelidonate) are presented. A variety of pronucleophiles were used in combination with tert-butanol as solvent and potassium tert-butoxide as base, using conventional heating methods and microwave conditions.
- Marshall, Laura J.,Cable, Karl M.,Botting, Nigel P.
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- A general methodology for the synthesis of substituted phenols from pyranone precursors
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Phenols are an important group of organic compounds,1 with many natural products such as polyketides, coumarins and flavonoids containing mono- or poly-phenolic moieties. The synthesis of substituted phenols from pyranone precursors is presented. A variety of pronucleophiles were used in combination with tert-butanol as solvent and potassium tert-butoxide as base, using both conventional heating methods and microwave conditions. Copyright
- Marshall, Laura J.,Cable, Karl M.,Botting, Nigel P.
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p. 457 - 459
(2011/04/24)
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