cas 1195-91-1, 2-BROMO-5,5-DIMETHYL-1,3-CYCLOHEXANDIONE

Articles about 1195-91-1Total 23 be found

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Synthesis of some novel chloro-/aryl-substituted-5,5-dimethyl-2-cyclohexenones
Two novel structural isomers: the dihalo-5,5-dimethyl-2-cyclohexenones were synthesized. Regioselective Suzuki-Miyaura cross coupling reaction of the isomers with nine different aryl boronic acids afforded eighteen novel compounds: the 2-aryl-3-chloro-5,5-dimethyl-2-cyclohexenones and the 3-aryl-2-chloro-5,5-dimethyl-2-cyclohexenones in 90–95% yields, which were characterized spectroscopically by IR, NMR and MS. The single crystal X-Ray diffraction ORTEP views of four representative compounds unambiguously confirm the formation of substituted cyclohexenones.
HariPrasad, S.,Jeevan Chakravarthy, A. S.,Pavan, K. P.,Venkatesh, G. B.
(2020)
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Synthesis of various cyclopropyl methyl bromide and its derivatives from ketones and/or aldehydes and some β-dicarbonyl compounds in the presence of BrCN and Et3N
The ultimate goal in this paper has been developed for the synthesis of structurally various bromomethyl cyclopropane via an α-bromoketone and/or aldehydes with ethyl cyanoacetate or malononitrile and cyanogen bromide (BrCN) in the presence of Et3N to give products in excellent yields within about 3?s. All structures were characterized by IR, 1H-NMR, 13C-NMR, and Mass spectroscopy techniques. The reaction mechanism was discussed.
Gholizadeh, Saeed,Safa, Kazem D.,Noroozi Pesyan, Nader
p. 1239 - 1253
(2019)
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Cantlon,I.J. et al.
p. 46 - 52
(1961)
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Design and application of 2,2-dibromodimedone as organic brominating reagent for asymmetric bromination of 1,3-dicarbonyl compounds and ketones catalysed by chiral amino acids
A green and ecofriendly enantioselective a-bromination of carbonyl and 1,3-dicarbonyl compounds is reported involving the synthesis of a novel organic brominating source. The organic brominating reagent can be recovered after each cycle, rebrominated and
Goswami, Papori,Baruah, Abhilasha,Das, Babulal
p. 1483 - 1487
(2009)
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Synthesis of the new heterocyclic system 7,8-dihydro-6H-benzotetrazolothiadiazine and derivatives
New N,N-disubstituted 7,7-dimethyl-7,8-dihydro-6H-benzotetrazolothiadiazine-9-amines were synthesized from sodium 1-amino-1H-tetrazole-5-thiolate and 2-bromo-5,5-dimethylcyclohexane-1,3-dione in multiple steps. The compounds were characterized by 13
Rezaeian, Shima,Rahimizadeh, Mohammad,Eshghi, Hossein,Bakavoli, Mehdi,Haghbin, Kamahldin,Saadatmandzadeh, Mohammad
p. 339 - 341
(2014)
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A mild and environmentally acceptable synthetic protocol for chemoselective α-bromination of β-keto esters and 1,3-diketones
A wide variety of unsubstituted β-keto esters can be brominated chemoselectively to the corresponding α-monobromo-β-keto esters by using a combination of vanadium pentoxide, hydrogen peroxide and ammonium bromide in a biphasic system, dichloromethane-wate
Khan, Abu T.,Goswami, Papori,Choudhury, Lokman H.
p. 2751 - 2754
(2006)
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Novel Metal- and Mineral-Acid-Free Synthesis of Organic Ammonium Tribromides and Application of Ethylenephenanthrolium Bistribromide for Bromination of Active Methylene Group of 1,3-Diketones and β-Ketoesters
A novel procedure for the preparation of organic ammonium tribromides (OATBs) is described from their corresponding bromides. Quaternary ammonium bromides (QABs) and a N,N′-heterocyclic dibromide are efficiently oxidized to their corresponding monotribromides and bistribromide by m-chloroperbenzoic acid (MCPBA) in the presence of 2 and 4 equiv of KBr, respectively. The reactions are carried out in an aqueous medium without the use of any mineral acid or metal catalyst/promoters. A variety of tribromides are synthesized in very good yields including a hitherto unknown reagent, 1,10-(ethane-1, 2-diyl)phenanthrolinediium bistribromide (EPDBT). EPDBT is investigated as brominating agent and found to be highly effective for selective bromination of active methylene groups of a variety of 1,3-diketones and β-ketoesters. GRAPHICAL ABSTRACT.
Dey, Rupa Rani,Paul, Bappi,Dhar, Siddhartha Sankar
p. 724 - 736
(2015)
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A quick, mild and efficient bromination using a CFBSA/KBr system
Bromination is a fundamental transformation in organic chemistry and brominated compounds as building blocks are of paramount importance in organic synthesis. In our study, we have developed an efficient method of bromination by using a CFBSA/KBr system at room temperature in a short reaction time. Notably, this approach has been proven to be applicable to a range of substrates including 1,3-diketones and β-keto esters, phenols, aromatic amines and heteroarenes with good to excellent yields.
Jiang, Pan-Pan,Yang, Xian-Jin
p. 90031 - 90034
(2016/10/09)

Monobromomalononitrile: An efficient regioselective mono brominating agent towards active methylene compounds and enamines under mild conditions
The potential of monobromomalononitrile (MBM) as a convenient source of cationic bromine in organic bromination reaction has been explored. Studies reveal that MBM can be a good substitute for N-bromosuccinimide (NBS) in various respects. Enamines and act
Pathak, Sudipta,Kundu, Ashis,Pramanik, Animesh
p. 10180 - 10187
(2014/03/21)

IMINO COMPOUNDS AS PROTECTING AGENTS AGAINST ULTRAVIOLET RADIATIONS
The present invention relates to compounds having the general Formula I: which absorb UV radiations and protect biological materials as well as non-biological materials from damaging exposure to UV radiations. The present invention also relates to formulations and compositions comprising such compounds for use in absorbing UV radiations and in protecting biological materials as well as non-biological materials against UV radiations.
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(2014/01/08)

Selective formation of spiro dihydrofurans from one-pot reaction of dimedone with BrCN and aldehydes in the presence of Et3N
Reaction of 5,5-dimethylcyclohexane-1,3-dione (dimedone), aldehydes and cyanogen bromide in the presence of triethylamine leads to the selective formation of spiro dihydrofurans in moderate to good yields at room temperature.
Noroozi Pesyan, Nader,Shokr, Alireza,Behroozi, Mohammad,Sahin, Ertan
p. 565 - 575
(2013/07/27)

Facile and efficient method for oc-monobromination of dicarbonyl compounds with N-bromosuccinimide
The a-monobrominated products were prepared fast in presence of p-TsOH as catalyst in very high yields using various 1,3-diketones and β-keto-esters with N-bromosuccinimide in CH2C12.
Fang, Li-Zhen,Shen, Jiu-Ming,Lv, Qing-Hua,Yan, Fu-Lin
experimental part
p. 3425 - 3427
(2012/02/04)

FUSED IMIDAZO [3, 2 - D] PYRAZINES AS PI3 KINASE INHIBITORS
There is provided compounds of formula (I), wherein A1, A2, A3, A4, n, the dotted lines, B1, B1a, B2, B2a, B3, B3a, B4, B4a, R2 and R3 have meanings given in the description, and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein kinase (e.g. a PI3-K and/or mTOR) is desired and/or required, and particularly in the treatment of cancer or a proliferative disease.
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(2011/04/24)

FUSED THIAZOLE AND THIOPHENE DERIVATIVES AS KINASE INHIBITORS
A series of fused bicyclic thiazole and thiophene derivatives which are substituted in the 2-position by an optionally substituted morpholin-4-yl moiety, and in the 4-position by hydroxy, oxo or an amine moiety, being selective inhibitors of PI3 kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions. (I)
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(2009/07/17)

Ethylenebis(N-methylimidazolium) ditribromide (EBMIDTB): An efficient reagent for the monobromination of 1,3-diketones and β-ketoesters
Ethylenebis(N-methylimidazolium) ditribromide, a stable crystalline solid, is easily prepared by reaction of the corresponding dibromide salt with bromine in n-hexane. 1,3-Diketones and β-ketoesters can be brominated chemoselectively to the corresponding α-monobrominated products by using this reagent at 0-5°C. Under the same reaction conditions, diethyl malonate, ethyl cyanoacetate, and malonitrile were monobrominated at moderate yield.
Hosseinzadeh, Rahman,Tajbakhsh, Mahmood,Mohadjerani, Maryam,Lasemi, Zahra
experimental part
p. 57 - 60
(2010/03/30)

4-(1,3-Thiazol-2-yl)morpholine derivatives as inhibitors of phosphoinositide 3-kinase
4-(1,3-Thiazol-2-yl)morpholine derivatives have been identified as potent and selective inhibitors of phosphoinositide 3-kinase. The SAR data of selected examples are presented and the in vivo profiling of compound 18 is shown to demonstrate the utility of this class of compounds in xenograft models of tumor growth.
Alexander, Rikki,Balasundaram, Ahrani,Batchelor, Mark,Brookings, Daniel,Crepy, Karen,Crabbe, Tom,Deltent, Marie-France,Driessens, Frank,Gill, Andrew,Harris, Sue,Hutchinson, Gillian,Kulisa, Claire,Merriman, Mark,Mistry, Prakash,Parton, Ted,Turner, James,Whitcombe, Ian,Wright, Sara
scheme or table
p. 4316 - 4320
(2009/04/06)

FUSED THIAZOLE DERIVATIVES AS KINASE INHIBITORS
A series of 5,5-dimethyl-5,6-dihydro-1,3-benzothiazol-7(4H)-one and 7,7-dimethyl-5,6,7,8-tetrahydro-4H-[1,3]thiazolo[5,4-c]azepin-4-one derivatives, and analogues thereof, which are substituted in the 2-position by an optionally substituted benzofused mor
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(2008/06/13)

Achieving multi-isoform PI3K inhibition in a series of substituted 3,4-dihydro-2H-benzo[1,4]oxazines
The SAR and pharmacokinetic profiles of a series of multi-isoform PI3K inhibitors based on a 3,4-dihydro-2H-benzo[1,4]oxazine scaffold are disclosed.
Perry, Benjamin,Alexander, Rikki,Bennett, Gavin,Buckley, George,Ceska, Tom,Crabbe, Tom,Dale, Verity,Gowers, Lewis,Horsley, Helen,James, Lynwen,Jenkins, Kerry,Crepy, Karen,Kulisa, Claire,Lightfoot, Helen,Lock, Chris,Mack, Stephen,Morgan, Trevor,Nicolas, Anne-Lise,Pitt, Will,Sabin, Verity,Wright, Sara
scheme or table
p. 4700 - 4704
(2009/04/08)

Microwave-mediated synthesis of some novel heterocycles containing thiazole, oxazole, thiazine, oxazine, thiadiazine and triazolo-thiadiazine moiety
5,5-Dimethyl cyclohexane-1,3-dione 1 has been brominated to yield 2-bromo-5,5-dimethyl cyclohexane-1,3-dione 2 which on further reaction with substituted thiocarbamides, carbamides, 2-aminothiophenols, 2-aminophenol, thiocarbohydrazones, thiosemicarbazones and triazoles has furnished 2-substituted imino-5,5-dimethyl-2,3,5,6 -tetrahydro-4H-benzothiazol-7-one 3, 2-substituted imino-5,5-dimethyl-2,3,5,6,-tetrahydro-4H-benzoxazol-7-one 4, 7-substituted-2,2-dimethyl-2,3-dihydro-1H,10H -phenothiazin-4-one 5, 2,2-dimethyl-2,3-dihydro-1H,10H-phenoxazin-4-one 6, Schiff base of 2-hydrazino-6,6-dimethyl-6,7-dihydro-4H,5H-benzo[1,3,4]thiadiazin-8-one 7, Schiff base of 2-amino-6,6-dimethyl-6,7-dihydro-4H,5H-benzo[1,3,4] thiadiazin-8-one 8 and 3-substituted alkyl-7,7-dimethyl-7,8-dihydro-5H,6H-1,2,4- triazolo[3,4-b][1,3,4]benzothiadiazin-9-one 9 respectively. All the final compounds have been synthesized by microwave irradiation as well as by conventional method.
Dabholkar, Vijay V.,Mishra, Sushil Kumar J.
p. 2112 - 2117
(2007/10/03)

A green approach for efficient α-halogenation of β-dicarbonyl compounds and cyclic ketones using N-halosuccinimides in ionic liquids
Room temperature ionic liquids (ILs) are used as a green recyclable reaction media for the α-monohalogenation of 1,3-diketones, β-keto-esters and cyclic ketones with N-halosuccinimides in excellent yields in the absence of a catalyst. The recovered ionic liquid was reused five to six times with consistent activity.
Meshram,Reddy,Vishnu,Sadashiv,Yadav
p. 991 - 995
(2007/10/03)

FUSED THIAZOLE DERIVATIVES AS KINASE INHIBITORS
A series of 5,6-dihydro-l,3-benzothiazol-7(4H)-one derivatives, and analogues thereof, which are substituted in the 2-position by an optionally substituted morpholin-4-yl moiety, being selective inhibitors of PD kinase enzymes, are accordingly of b.enefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions.
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(2008/06/13)

Bromination Mediated by a Vanadium(V)-Peroxo Complex (GlyH = Glycine): a Functional Model for the Enzyme Bromoperoxidase
The reaction of potassium bromide with aromatic compounds C6H4XY (X=NHCOMe, Y=H or 4-Me; X=CHO, Y=2-OH) and 5,5-dimethylcyclohexa-1,3-dione in aqueous media in the presence of produces the corresponding brominated compounds; the reaction is proposed to be a mimic for the enzyme bromoperoxidase.
Bhattacharjee, Manish,Ganguly, Somenath,Mukherjee, Joy
p. 80 - 81
(2007/10/03)

α-BROMINATION OF KETONES WITH THE BROMINE COMPLEX OF POLY(STYRENE-CO-4-VINYLPYRIDINE)
The bromine complex of poly(styrene-co-4-vinylpyridine) reacted with ketones and 1,3-diketones to form α-bromo or α,α-dibromo products in high yields.
Sket, Boris,Zupan, Marko
p. 2481 - 2488
(2007/10/02)

BROMINATION OF KETONES AND PHENOLS WITH 4-(TRIBROMOMETHYL)QUINAZOLINE
4-(Tribromomethyl)quinazoline, 1, in benzene behaves as a brominating agent towards ketones (in the enol form) and phenols.The reaction has the features of a polar reaction, notwithstanding the nature of the solvent.Ketones and phenols behave as nucleophiles, and attack a bromine atom of the brominating agent.
Mencarelli, Paolo,Stegel, Franco
p. 83 - 86
(2007/10/02)