Preparation of heterocyclic amines by an oxidative amination of zinc organometallics mediated by CuI: A new oxidative cycloamination for the preparation of annulated indole derivatives
Functionalized heterocyclic zinc reagents are easily aminated by an oxidative amination reaction of zinc amidocuprates prepared from various lithium amides. For the oxidation step, PhI(OAc)2 proved to be the best reagent. The required heterocyc
Kienle, Marcel,Wagner, Andreas J.,Dunst, Cora,Knochel, Paul
supporting information; experimental part
p. 517 - 523
(2011/10/09)
Preparation of heterocyclic amines via a copper(i)-mediated oxidative cross-coupling of organozinc reagents with lithium amides
Functionalized heteroaromatic amines are readily prepared by the oxidative coupling of polyfunctional zinc amidocuprates using PhI(OAc)2 as oxidant. Various sensitive heterocyclic organometallics undergo this oxidative cross-coupling reaction furnishing aminated heteroaromatics. A high functional group tolerance and relative insensibility to steric hindrance characterize this general amination reaction. A practical procedure for the preparation of protected primary and secondary as well as tertiary heteroaryl amines is described. Georg Thieme Verlag Stuttgart - New York.
Dunst, Cora,Kienle, Marcel,Knochel, Paul
experimental part
p. 2313 - 2318
(2010/08/21)
Oxidative amination of heteroaromatic zinc reagents mediated by PhI(OAc)2
The oxidative amination of functionalized heterocycles has been achieved by using readily available heterocyclic zinc reagents and lithium amides. PhI(OAc)2 proved to be a suitable reagent for this oxidative amination
Kienle, Marcel,Dunst, Cora,Knochel, Paul
supporting information; experimental part
p. 5158 - 5161
(2009/12/28)
More Articles about upstream products of 1195901-24-6