- Cyclopentanone Derivatives from 5-Hydroxymethylfurfural via 1-Hydroxyhexane-2,5-dione as Intermediate
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An efficient strategy for the conversion of biomass derived 5-hydroxymethylfurfural (HMF) into 2-hydroxy-3-methylcyclopent-2-enone (MCP) by an intramolecular aldol condensation of 1-hydroxyhexane-2,5-dione (HHD) has been developed. Further transformations of MCP towards the diol, enol acetate, levulinic acid and N-heterocyclic compounds are also reported.
- Wozniak, Bartosz,Spannenberg, Anke,Li, Yuehui,Hinze, Sandra,de Vries, Johannes G.
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- SMALL MOLECULE INHIBITORS OF NF-kB INDUCING KINASE
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The present invention relates to compounds that inhibit NIK and pharmaceutical compositions comprising such compounds and methods of using the same. These compounds and pharmaceutical compositions are envisaged to be useful for preventing or treating diseases such as cancer (such as B-cell malignancies including leukemias, lymphomas and myeloma), inflammatory disorders, autoimmune disorders, immunodermatologic disorders such as palmoplantar pustulosis and hidradenitis suppurativa, and metabolic disorders such as obesity and diabetes.
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Page/Page column 203; 204
(2020/12/11)
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- Process for preparing cyclopentenone derivatives
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A process for preparing cyclopentenone derivatives represented by the formula: STR1 wherein R1 is methyl or ethyl, and R2 is hydrogen, methyl or acetyl, characterized in that a 1,4-diketone derivative represented by the formula: wherein R1 and R2 are as defined above is cyclized in the presence of a basic catalyst.
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