1196486-69-7Relevant articles and documents
HETEROCYCLIC COMPOUNDS, PREPARATION METHODS THEREFOR, AND METHODS OF USES THEREOF
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Paragraph 155, (2021/01/23)
Provided herein are novel heterocyclic compounds, for example, compounds having Formula I. Also provided herein are methods of preparing the compounds and methods of using the same, for example, in inhibiting TGF-beta mediated signaling and/or for treating cancer.
5-MEMBERED HETEROCYCLE FUSED WITH [3,4-D]PYRIDAZINONE, AND MANUFACTURING METHOD, PHARMACEUTICAL COMPOSITION, AND APPLICATION THEREOF
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Paragraph 0144; 0145, (2019/04/29)
The present invention provides a compound comprising a 5-membered heterocycle fused with a pyridazinone, wherein the compound is used as an FGFR kinase inhibitor, and a manufacturing method and application thereof. The invention specifically provides a co
PYRAZOLE DERIVATIVES AS NHIBITORS OF THE WNT SIGNALLING PATHWAY
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Page/Page column 6; 35, (2019/09/18)
The present invention relates to a novel class of compounds as inhibitors of the Wnt signalling pathway. The best compounds showed potencies in the low micromolar range and high efficacies (> 80%) together with good microsomal stability. Furthermore, in v
Synthesis of 1 - (N - Boc - 4 - piperidyl) - 4 - pyrazole boric acid frequency alcohol ester
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Paragraph 0020-0022, (2017/06/02)
The invention discloses a method for synthesis of 1-(N-Boc-4-piperidine)-4-pyrazoleboronic acid pinaol ester. According to the method, N-Boc-4-piperidone serves as the raw material and reacts with hydrazine hydrate, N-Boc-4-piperidine hydrazine is generated through reduction, then dehydration condensation reaction is conducted between N-Boc-4-piperidine hydrazine and 2-halogenate malonaldehyde so that a 1-(N-Boc-4-piperidine)-4-chlorine/bromine pyrazol midbody can be obtained effectively, and in the presence of metallic nickel, metallic nickel catalytic coupling reaction ester forming is conducted on the midbody under a mild condition to obtain the 1-(N-Boc-4-piperidine)-4-pyrazoleboronic acid pinaol ester. The whole process is easy to operate, conditions are mild, and untralow-temperature reaction is not needed; meanwhile, required raw materials are cheap and easy to obtain, reproducibility is high, and the method is suitable for industrialized large-scale production.
NOVEL PIPERIDINE DERIVATIVES
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Page/Page column 72, (2016/06/28)
The invention relates to a compound of formula (I) wherein A1, A2 and R1to R3 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.
BICYCLIC HETEROCYCLE DERIVATIVES AND THEIR USE AS GPCR MODULATORS
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Page/Page column 56, (2010/04/03)
The present invention relates to Bicyclic Heterocycle Derivatives of Formula (I), compositions comprising a Bicyclic Heterocycle Derivative, and methods of using the Bicyclic Heterocycle Derivatives for treating or preventing obesity, diabetes, a diabetic
GPR119 Receptor Agonists
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Page/Page column 21, (2009/12/05)
Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of metabolic diseases and disorders such as, for example, type II diabetes mellitus.