New approaches for the synthesis of 1,3,4-thiadiazole and 1,2,4-triazole derivatives with antimicrobial activity
The thiosemicarbazide derivatives 3a and 3b were cyclized in the presence of concentrated sulfuric acid to give the 5-cyanomethyl-1,3,4-thiadiazole derivatives 4a and 4b, respectively. The latter products were used for many heterocyclic transformations to
Wardakhan, Wagnat W.,El-Sayed, Nahed N. E.
experimental part
p. 790 - 804
(2009/10/15)
Activated nitriles in heterocyclic synthesis. Part 6: Novel synthesis of thiadiazolo pyridine derivatives
Several new thiadiazolo pyridine, thiazole and coumarin derivatives were synthesized via the reaction of 2-cyanomethylthiadiazole with cinnamonitriles, mercaptoacetic acid and salicylaldehyde.
Sowellum, S. Z. A.,Khodeir, M. N. M.,El-Amin, S. M.,Elagamey, A. A.
p. 533 - 534
(2007/10/02)
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