119714-13-5

Basic information

• Product Name: (S)-5-(2-AMinopropyl)-2-MethoxybenzenesulfonaMide
• Synonyms: (S)-5-(2-AMinopropyl)-2-MethoxybenzenesulfonaMide;Tamsulosin Related Compound ((S)-5-(2-Aminopropyl)-2-Methoxybenzenesulfonamide);Tamsulosin Impurity 1
• CAS NO: 119714-13-5
• Molecular Formula: C₁₀H₁₆N₂O₃S
• Molecular Weight: 244.31064
• Mol File: 119714-13-5.mol

Chemical Properties

• Melting Point: 273-276 °C (decomp)
• Boiling Point: 445.5±55.0 °C(Predicted)
• Appearance: /
• Density: 1.247±0.06 g/cm3(Predicted)
• PKA: 10.08±0.60(Predicted)
• CAS DataBase Reference: (S)-5-(2-AMinopropyl)-2-MethoxybenzenesulfonaMide(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-5-(2-AMinopropyl)-2-MethoxybenzenesulfonaMide(119714-13-5)
• EPA Substance Registry System: (S)-5-(2-AMinopropyl)-2-MethoxybenzenesulfonaMide(119714-13-5)

Safety Data

• Hazardous Substances Data: 119714-13-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Methoxamine is used as a vasopressor agent for the treatment of hypotension. It functions by stimulating alpha-adrenergic receptors in blood vessels, leading to constriction and an increase in blood pressure. This application is particularly relevant in the context of anesthesia, where maintaining stable blood pressure is crucial for patient safety and outcomes.
Additionally, given its chemical structure and properties, methoxamine may have potential applications in other areas of medicine, such as the development of new drugs targeting specific receptors or pathways. However, further research would be required to explore these possibilities and validate their efficacy and safety.

Upstream product

• 944395-49-7 5-(2-hydroxyiminopropyl)-2-methoxybenzenesulfonamide 
• 116091-63-5 2-methoxy-5-(2-oxopropyl)benzenesulfonamide 
• 112244-38-9 (+/-)-5-(2-aminopropyl)-2-methoxybenzenesulfonamide 

Relevant articles and documents

NOVEL PROCESS FOR THE SYNTHESIS OF ENANTIOMERICALLY PURE 2-METHOXY-5-[(2R)-2-(4-ALKYLPIPERAZIN-L-YL)PROPYL]-BENZENESULFONAMIDE

Where R is C1-C3 alkyl, alkenyl A novel process for synthesis of compound of Formula 1 comprising steroselective catalytic reduction of compound of Formula IV under hydrogen gas pressure to obtain an intermediate compound of Formula II, which on coupling in presence of coupling agent and base in presence of organic solvent to obtain compound of Formula X, Formula X on reacting with deprotecting agent in presence of organic solvent results in formation of compound of Formula XI, condensation of Formula XI with alkyl halide results in formation of compound of Formula I.

METHOD FOR PRODUCING OPTICALLY ACTIVE COMPOUND

PROBLEM TO BE SOLVED: To provide a method for simply producing (R)-(-)-5-[2-[2-(2-ethoxyphenoxy)ethylamino]-2-methylethyl]-2-methoxybenzenesulfonamide hydrochloride salt and an intermediate for the same at a reduced cost. SOLUTION: This method for producing the optically active compound expressed by chemical formula (6) comprises subjecting a compound expressed by chemical formula (5) to optical resolution with an optical resolution agent which has an optically active saccharide derivative as an asymmetry identifying part.