119789-44-5Relevant articles and documents
Investigation into the functional impact of the vancomycin C-ring aryl chloride
Pinchman, Joseph R.,Boger, Dale L.
, p. 4817 - 4819 (2013)
A vancomycin aglycon analogue that possesses a reduced C-ring and an intact E-ring chloride was prepared and its antimicrobial activity towards Staphylococcus aureus and binding affinity to model cell wall ligands were established. Comparison of the derivative with a series of vancomycin aglycon analogues that possess and lack the chloro substituents on the aryl C- and E-rings defines the impact and further refines the role the C-ring chloride plays in promoting both target binding affinity and binding selectivity for d-Ala-d-Ala and its impact on antimicrobial activity.
Structure-activity relationship studies of a series of antiviral and antibacterial aglycon derivatives of the glycopeptide antibiotics vancomycin, eremomycin, and dechloroeremomycin
Printsevskaya, Svetlana S.,Solovieva, Svetlana E.,Olsufyeva, Eugenia N.,Mirchink, Elena P.,Isakova, Elena B.,De Clercq, Erik,Balzarini, Jan,Preobrazhenskaya, Maria N.
, p. 3885 - 3890 (2007/10/03)
N-Adamantyl-1)methyl, N-(adamantyl-2), and N-(ω-aminodecyl) amides of vancomycin, eremomycin, and dechloroeremomycin aglycons and their des-(N-Me-D-Leu) derivatives were synthesized and their antibacterial and anti-HIV activities were investigated. Carbox
