Efficient synthesis of nevirapine analogs to study its metabolic profile by click fishing
Knowledge of the biotransformation and pharmacokinetics of the antiretroviral agent nevirapine is still insufficient. In order to trace rash inducing metabolites of nevirapine, we devised a short and efficient multi-gram synthesis of a nevirapine analog that can be coupled to azide containing compounds by click chemistry.
Bernard, Sylvain,Defoy, Daniel,Dory, Yves L.,Klarskov, Klaus