INTRAMOLECULAR METAL CATALYZED KHARASCH CYCLIZATION OF OLEFINIC α-HALO ESTERS AND ACIDS
Functionalized carbocyclyc compounds are produced by intramolecular Kharasch radical cyclization reactions catalyzed by various transition metal complexes.Several unsaturated mono-α-haloesters and acids can be efficiently transformed to γ-halocarboxyl and γ-lactone carbocycles via exo closure of a 5-hexenyl type radical intermediate.The cyclization methodology is useful for synthesis of both fused and bridged carbocycles.
Lee, Gary M.,Weinreb, Parvez,Weinreb, Steven M,
p. 4671 - 4678
(2007/10/02)
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