- Muraminomicins, novel ester derivatives: in vitro and in vivo antistaphylococcal activity
-
Novel muraminomicin derivatives with antimicrobial activity against methicillin-resistant Staphylococcus aureus (MRSA) were synthesized by esterification of the hydroxy group on the diazepanone ring of muraminomicin Z1. Compound 1b (DS14450354)
- Kagoshima, Yoshiko,Tokumitsu, Akane,Masuda, Takeshi,Namba, Eiko,Inoue, Harumi,Sugihara, Chika,Yokoyama, Mizuka,Yamamoto, Yuko,Suzuki, Keiko,Iida, Kouki,Tamura, Akihiro,Fujita, Yoko,Takatsu, Toshio,Konosu, Toshiyuki,Koga, Tetsufumi
-
-
Read Online
- Phenylalanine derivative and proteinase inhibitor
-
A phenylalanine derivative having the formula (I): X represents hydrogen, (b) hydroxy, (c) nitro, or (d) C?-C? alkyloxy which may be substituted with phenyl; Y represents wherein R1 and R2 are, independently, (a) hydrogen, provided that both R1 and R2 are not hydrogen at the same time; (b) phenyl, which may be substituted with (i) phenylcarbonyl, (ii) C?-C? alkylcarbonyl, (iii) C?-C? alkyl, which may be further substituted with C?-C? alkoxycarbonyl or hydroxycarbonyl, (iv) C?-C? alkenyl, which may further be substituted with C?-C? alkoxy-carbonyl, (v) trifluoromethyl; (c) pyridyl, which may be substituted with C?-C? alkoxy; (d) C?-C? alkyl, which may be substituted with (i) hydroxy, (ii) C?-C? alkoxycarbonyl, (iii) pyridyl, or (iv) phenyl, which may be further substituted with C?-C? alkylaminocarbonyl; (e) C?-C? cycloalkyl, which may be substituted with C?-C? alkyl; or (f) R1 and R2 may form, with the nitrogen atom attached thereto, (i) piperidino, which may be substituted with phenylcarbonyl or (ii) pyrrolidyl, which may be substituted with C?-C? alkoxycarbonyl; or a pharmaceutically acceptable salt thereof. This phenylalanine derivative is effective as a proteinase inhibitor.
- -
-
-