- Structure-affinity relationships of 12-sulfonyl derivatives of 5,8,8a,9,10,11,12,12a,13,13a-decahydro-6H-isoquino[2,1-g][1,6] naphthyridines at α-adrenoceptors
-
Analogues of the potent α2-adrenoceptor antagonist (8aR,12aS,13aS)-5,8,8a,9,10,11,12,12a,13,13a-decahydro-3-methoxy-12- (methylsulfonyl)-6H-isoquino[2,1-g][1,6]naphthyridine (1b) were prepared and evaluated for α1- and α2-
- Clark,Repke,Berger,Nelson,Kilpatrick,Brown,MacKinnon,Clague,Spedding
-
p. 705 - 717
(2007/10/02)
-
- PREPARATION OF ENANTIOMERICALLY PURE DECAHYDRO-6H-ISOQUINONAPHTHYRIDINES UTILIZING THE OPENSHAW-WHITTAKER HEXAHYDROBENZOQUINOLIZINONE RESOLUTION
-
The (8aR,12aS,13aS)-decahydro-6H-isoquinonaphthyridine sulfonamides 1a,b were prepared from (+)-(3R,11bS)-3-cyanoethylhexahydrobenzoquinolizinones 3a,b.These key intermediates were obtained by resolution of (+/-)-3a,b with (+)-camphorsulfonic acid in ethyl acetate according to the conditions used in the Openshaw-Whittaker synthesis of (-)-emetine.
- Clark, Robin D.,Kern, John R.,Kurz, Lilia J.,Nelson, Janis T.
-
p. 353 - 366
(2007/10/02)
-
- Optical isomers of sulfonyldecahydro-8H-isoquino-(2,1-G)(1,6) naphthyridines and related compounds useful as α2 -blockers
-
Compounds of the formula (1): STR1 in which: X and Y are independently hydrogen, hydroxy, lower alkyl, lower alkoxy or halo, or X and Y taken together is methylenedioxy or ethylene-1,2-dioxy, and R is lower alkyl, optionally substituted phenyl, --(CH2)m OR1 or --NR1 R2, wherein m is an integer of 1 to 6 and R1 and R2 are independently hydrogen or lower alkyl, or --NR1 R2 taken together is a heterocycle of the formula: STR2 wherein A is --CH2 --, --NR1 -- or oxygen; or a pharmaceutically acceptable salt thereof, are useful as selective α2 -blockers.
- -
-
-