Organocatalytic anti/-selective mannich reactions with fluorinated aldimines: synthesis of anti-γ-fluoroalkyl-γ-amino alcohols
The asymmetric Mannich reaction between fluoroalkyl aldimines and aldehydes catalyzed by αα-diphenylprolinol trimethylsilyl ether is reported. The corresponding Mannich adducts were reduced in situ to afford anti-β-alkyl-γ-fluoroalkyl-γ-amino alcohols in
Fustero, Santos,Mojarrad, Fatemeh,Carrion, Maria Dolores Perez,Sanz-Cervera, Juan F.,Acen, Jose Luis
experimental part
p. 5208 - 5214
(2010/01/18)
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