- Aggregation induced emission in the rotatable molecules: The essential role of molecular interaction
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Aggregation-induced emission (AIE) compounds, dye2 and dye3, with a rotatable N-N single bond and aza-crown-ether, have been synthesized. The fluorescence intensities of both dyes are very weak in THF, while become extraordinarily strong in a mixture of H2O-THF (v/v 95%). They are increased by 88.9 and 70.7 times, respectively, indicating enhanced blue-green fluorescence emissions. The λem of these two compounds in different states has been well studied. Besides this, dye1 and dye2 were characterized by single crystal X-ray structural determination. The results show that molecular interactions are formed in the particles, which considerably restrict the intramolecular vibration and rotation. The Royal Society of Chemistry 2012.
- Yu, Zhipeng,Duan, Yaya,Cheng, Longhuai,Han, Zhili,Zheng, Zheng,Zhou, Hongping,Wu, Jieying,Tian, Yupeng
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Read Online
- Self-assembly of a series of thiocyanate complexes with high two-photon absorbing active in near-IR range and bioimaging applications
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Abstract A series of novel complexes bearing high fluorescence quantum yields and showing the peak two-photon absorption (2 PA) cross-sections in the near-infrared region, Zn(SCN)2L2(1), [Cd(SCN)2L2]n(2), Co(SCN)2L4(3), Ni(SCN)2L4(4), [CdHgL2(SCN)4]n(5) and [MnHg(SCN)4L2]n(6), containing functional chromophore (L = (E)-(4-diethyl anilinostyryl)pyridine), were synthesized in high yields. Crystal structures of all the complexes were confirmed. Hetero-metal complexes (5, 6: L:M = 1:1) present much higher two-photon absorption (2 PA) cross-sections (σ) in comparison with those of the homo-metal complexes (L:M = 4:1 in 3 and 4, L:M = 2:1 in 1 and 2) and the free ligand (L) which may due to the fact that the hetero-metal complexes have more bridged anions (SCN-), conjugated subunits -[Hg(SCN)2M]- and -[Hg2(SCN)4M2]-. In addition, the results revealed that 2 PA response was much enhanced for the Zn(SCN)2L2 and two-photon fluorescence cell imaging experiment proved its potential application.
- Li, Dandan,Zhang, Qiong,Wang, Xuchun,Li, Shengli,Zhou, Hongping,Wu, Jieying,Tian, Yupeng
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Read Online
- NOVEL CATHODE BUFFER LAYER MATERIAL AND ORGANIC PHOTOELECTRIC DEVICE INCLUDING SAME
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The present invention relates to a novel cathode buffer layer material and an organic photoelectric device including the same. When the novel compound of the present invention is applied to a cathode buffer layer of an organic photoelectric device, for example, an organic solar cell or an organic photodiode, there is an effect in which the surface characteristics of an electron transport layer are improved through the high dipole moment of the novel compound to thereby facilitate electron extraction from a photoactive layer to a cathode electrode and to reduce series resistance and leakage current, and accordingly, the performance of an organic optoelectronic device (organic solar cell, organic photodiode, etc.) to be manufactured can be remarkably improved, which is industrially advantageous.
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Paragraph 0178-0180
(2021/02/05)
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- Detection living body Fe2 + Double-photon fluorescence probe as well as preparation method and application thereof
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The invention relates to a pyrimidine-based dye which can be quickly regulated and controlled by light. Sensitive detection living body Fe2 + A double-photon fluorescence probe belongs to the field of organic fluorescent probes. The fluorescent probe is PyFe fluorescence probe, and the structural formula of PyFe fluorescence probe is as shown in formula (I). Fe In vivo can be accurately detected by the fluorescent probe. 2 + , Interference of other ionic amino acids in the cells is avoided. The probe has very fast response rate and high ion selectivity, can realize naked eye detection in vitro and also has good biocompatibility. The fluorescence confocal imaging experiment shows that the probe has good cell permeability, does not have toxic or side effects on cells and organisms, and has dual photonicity, so that the depth imaging of living animals or tissues can be realized.
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Paragraph 0042-0045; 0051-0054; 0060-0063
(2021/11/19)
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- Continuous-flow Synthesis of Aryl Aldehydes by Pd-catalyzed Formylation of Aryl Bromides Using Carbon Monoxide and Hydrogen
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A continuous-flow protocol utilizing syngas (CO and H2) was developed for the palladium-catalyzed reductive carbonylation of (hetero)aryl bromides to their corresponding (hetero)aryl aldehydes. The optimization of temperature, pressure, catalyst and ligand loading, and residence time resulted in process-intensified flow conditions for the transformation. In addition, a key benefit of investigating the reaction in flow is the ability to precisely control the CO-to-H2 stoichiometric ratio, which was identified as having a critical influence on yield. The protocol proceeds with low catalyst and ligand loadings: palladium acetate (1 mol % or below) and cataCXium A (3 mol % or below). A variety of (hetero)aryl bromides at a 3 mmol scale were converted to their corresponding (hetero)aryl aldehydes at 12 bar pressure (CO/H2=1:3) and 120 °C reaction temperature within 45 min residence time to afford products mostly in good-to-excellent yields (17 examples). In particular, a successful scale-up was achieved over 415 min operation time for the reductive carbonylation of 2-bromo-6-methoxynaphthalene to synthesize 3.8 g of 6-methoxy-2-naphthaldehyde in 85 % isolated yield. Studies were conducted to understand catalyst decomposition within the reactor by using inductively coupled plasma–mass spectrometry (ICP–MS) analysis. The palladium could easily be recovered using an aqueous nitric acid wash post reaction. Mechanistic aspects and the scope of the transformation are discussed.
- Hone, Christopher A.,Lopatka, Pavol,Munday, Rachel,O'Kearney-McMullan, Anne,Kappe, C. Oliver
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p. 326 - 337
(2018/11/23)
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- A process for preparing a broad pH fluorescent probe of the organic compound and use thereof (by machine translation)
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The present invention discloses a process for the preparation of a wide range of fluorescent probe in the pH of the organic compound, the organic compound can be produced according to the actual need to carry out any proportion of combination, and can be fixed in the hydrophilic high polymer further preparing and detecting water environment acidity and alkalinity of the product. The product can be realized to the pH value of the continuous measuring, thereby greatly improving the efficiency, sensitivity and repeatability. (by machine translation)
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Paragraph 0130; 0131
(2018/04/03)
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- Electrophilic Aromatic Formylation with Difluoro(phenylsulfanyl) methane
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Difluoro(phenylsulfanyl)methane (PhSCF 2 H) was found to undergo a reaction with aromatic compounds mediated by SnCl 4, through a thionium intermediate characterized by NMR and TD-DFT analyses, leading to the formation of a mixture of S, S ′-diphenyl dithioacetal and aromatic aldehyde which, after oxidative hydrolysis, provides the aromatic aldehyde in good to excellent yields. The salient feature of the present work is the reaction of activated aromatic compounds containing a deactivating ester functional group, leading to the formylated products in good yields.
- Betterley, Nolan M.,Kongsriprapan, Sopanat,Chaturonrutsamee, Suppisak,Deelertpaiboon, Pramchai,Surawatanawong, Panida,Pohmakotr, Manat,Soorukram, Darunee,Reutrakul, Vichai,Kuhakarn, Chutima
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p. 2033 - 2040
(2018/03/21)
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- Design, Synthesis, and Structure–Activity Relationship Analysis of Thiazolo[3,2-a]pyrimidine Derivatives with Anti-inflammatory Activity in Acute Lung Injury
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Acute lung injury (ALI) has a high lethality rate, and interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) contribute most to tissue deterioration in cases of ALI. In this study, we designed and synthesized a new series of thiazolo[3,2-a]pyrimidine derivatives based on a previously identified lead compound, and we evaluated their anti-inflammatory activities. Structure–activity relationship studies led to the discovery of two highly potent inhibitors. The two promising compounds were found to inhibit lipopolysaccharide (LPS)-induced IL-6 and TNF-α release in a dose-dependent manner in mouse primary peritoneal macrophages (MPMs). Furthermore, administration of these compounds resulted in lung histopathological improvements and attenuated LPS-induced ALI in vivo. Taken together, these data indicate that these novel thiazolo[3,2-a]pyrimidine derivatives could be developed as candidate drugs for the treatment of ALI.
- Chen, Lingfeng,Jin, Yiyi,Fu, Weitao,Xiao, Siyang,Feng, Chen,Fang, Bo,Gu, Yugui,Li, Chenglong,Zhao, Yunjie,Liu, Zhiguo,Liang, Guang
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supporting information
p. 1022 - 1032
(2017/07/11)
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- FTC-containing molecules: large second-order nonlinear optical performance and excellent thermal stability, and the key development of the “Isolation Chromophore” concept
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A series of second-order nonlinear optical (NLO) molecules, M1-M5, were designed and successfully synthesized through the convenient ‘‘click chemistry’’ reaction, which contain two different types of chromophore moieties, the FTC chromophore and nitro-based azo ones, according to the concept of “Isolation Chromophore”. All these five molecules possess excellent thermal stability and very large NLO performance, with an ultrahigh d33 value of 384 pm V?1 at the wavelength of 1950 nm achieved for M1, furthering the rational design of excellent NLO materials.
- Chen, Pengyu,Yin, Xiuyang,Xie, Yujun,Li, Shufang,Luo, Shiyu,Zeng, Huiyi,Guo, Guocong,Li, Qianqian,Li, Zhen
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supporting information
p. 11474 - 11481
(2016/12/18)
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- Monocarboxylate transporter 1 inhibitors as potential anticancer agents
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Potent monocarboxylate transporter 1 inhibitors (MCT1) have been developed based on α-cyano-4-hydroxycinnamic acid template. Structure-activity relationship studies demonstrate that the introduction of p-N, N-dialkyl/diaryl, and o-methoxy groups into cyanocinnamic acid has maximal MCT1 inhibitory activity. Systemic toxicity studies in healthy ICR mice with few potent MCT1 inhibitors indicate normal body weight gains in treated animals. In vivo tumor growth inhibition studies in colorectal adenocarcinoma (WiDr cell line) in nude mice xenograft models establish that compound 27 exhibits single agent activity in inhibiting the tumor growth.
- Gurrapu, Shirisha,Jonnalagadda, Sravan K.,Alam, Mohammad A.,Nelson, Grady L.,Sneve, Mary G.,Drewes, Lester R.,Mereddy, Venkatram R.
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supporting information
p. 558 - 561
(2015/05/27)
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- Discovery of indanone derivatives as multi-target-directed ligands against Alzheimer's disease
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A series of indanone derivatives were designed, synthesized, and tested using a variety of assays to assess their potential as anti-Alzheimer's disease (AD) agents. The investigations assessed the activities of the agents for the inhibition of cholinesterases (AChE and BuChE), the inhibition of amyloid beta (Aβ) self-assembly, and the catalysis of the disassembly of preformed Aβ oligomers and measured their antioxidant activities. Our results demonstrate that most of the synthesized compounds demonstrated good inhibitory activity against AChE with IC50 values in the nanomolar range. In particular, compounds 9 (IC50 Combining double low line 14.8 nM) and 14 (IC50 Combining double low line 18.6 nM) exhibited markedly higher inhibitory activities than tacrine and similar activities to donepezil. In addition, 9 and 14 significantly inhibited Aβ aggregation (inhibition rates of 85.5% and 83.8%, respectively), catalysed the disaggregation of Aβ fibrils generated by self-induced Aβ aggregation, and exhibited antioxidant activity. Furthermore, these two compounds can cross the blood-brain barrier (BBB) in vitro. These properties highlight the potential of these new compounds to be developed as multi-functional drugs for the treatment of Alzheimer's disease.
- Huang, Ling,Miao, Hui,Sun, Yang,Meng, Fanchao,Li, Xingshu
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p. 429 - 439
(2015/01/08)
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- Immobilization of Ru(III) complex on silica: A heterogenized catalyst for selective oxidation of alcohols in water at room temperature
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We have developed a heterogenized catalyst ('SiO2'-NH 2-RuIII) by the immobilization of [Ru(acac) 2(CH3CN)2]PF6 on SiO2. The catalyst was characterized by SEM, solid state NMR, EPR, FT-IR, ICP, and BET surface area analyses. 'SiO2'-NH2-RuIII catalyzed the selective oxidation of alcohols with periodic acid in water at room temperature. This protocol was applicable to the controlled oxidation of structurally diverse primary and secondary alcohols. The catalyst could be quantitatively recovered and reused up to six cycles without significant loss of catalytic activity.
- Ganesamoorthy,Muthu Tamizh,Shanmugasundaram,Karvembu
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p. 7035 - 7039
(2013/12/04)
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- Multitarget-directed benzylideneindanone derivatives: Anti-β-amyloid (Aβ) aggregation, antioxidant, metal chelation, and monoamine oxidase B (MAO-B) inhibition properties against Alzheimer's disease
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A novel series of benzylideneindanone derivatives were designed, synthesized, and evaluated as multitarget-directed ligands against Alzheimer's disease. The in vitro studies showed that most of the molecules exhibited a significant ability to inhibit self-induced β-amyloid (Aβ 1-42) aggregation (10.5-80.1%, 20 μM) and MAO-B activity (IC 50 of 7.5-40.5 μM), to act as potential antioxidants (ORAC-FL value of 2.75-9.37), and to function as metal chelators. In particular, compound 41 had the greatest ability to inhibit Aβ1-42 aggregation (80.1%), and MAO-B (IC50 = 7.5 μM) was also an excellent antioxidant and metal chelator. Moreover, it is capable of inhibiting Cu(II)-induced Aβ1-42 aggregation and disassembling the well-structured Aβ fibrils. These results indicated that compound 41 is an excellent multifunctional agent for the treatment of AD.
- Huang, Ling,Lu, Chuanjun,Sun, Yang,Mao, Fei,Luo, Zonghua,Su, Tao,Jiang, Huailei,Shan, Wenjun,Li, Xingshu
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p. 8483 - 8492,10
(2020/09/15)
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- Synthesis of aromatic aldehydes by a fast method involving Kornblum's reaction
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Aromatic aldehydes were synthesized by oxidation of corresponding halides with dimethyl sulfoxide on potassium bicarbonate by microwave irradiation. Short reaction time and high yields were obtained. Copyright Taylor & Francis Group, LLC.
- Bratulescu, George
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experimental part
p. 2748 - 2752
(2009/05/07)
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- A simple TiCl4 promoted arylation of orthoformate and benzyl ethers by N,N-dialkylarylamines
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N,N-Dialkylarylamines react with trimethyl orthoformate and TiCl4 under ambient conditions to give the corresponding formyl derivatives in 75-89% yields, whereas the corresponding arylated products are obtained from benzyl ethers and acetals in 42-78% yields.
- Periasamy, Mariappan,Kishorebabu, Neela,Natarajan Jayakumar
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p. 1955 - 1958
(2007/10/03)
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- Synthesis, crystal structures, and optical properties of a novel imidazole derivative and its Zn(II) complex
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A novel imidazole derivative, 1-[trans-4-(4-diethylaminostyryl)phenyl]imidazole (abbreviated as L), and its complex Zn(SCN)2L2 have been synthesized and fully characterized. Their crystal structures have been determined by X-ray diffraction. The molecular structure of L is approximately coplanar, the bond lengths of C-C and C-N are located between the normal double and single bonds, which show that L has a delocalized π-electron system in the molecule. In the molecular structure of Zn(SCN)2L2, zinc atom is four coordinated by two nitrogen atoms of the ligands (L) and two nitrogen atoms of thiocyanate to form a distorted tetrahedral geometry. The one-dimensional structure of Zn(SCN)2L2 is formed by C-H?S interactions and π-π interactions. They both crystallize in the noncentrosymmetric space group P21, and exhibit powder second-harmonic generation (SHG) efficiency approximately twenty times high as that of urea, indicating promising potential applications as useful nonlinear optical (NLO) materials.
- Jin, Feng,Li, Jian-feng,Zhou, Hong-ping,Wu, Jie-ying,Yang, Jia-xiang,Tian, Yu-peng,Jiang, Min-hua
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p. 202 - 207
(2007/10/03)
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- Novel non-steroidal/non-anilide type androgen antagonists with an isoxazolone moiety
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3-Substituted (Z)-4-(4-N,N-dialkylaminophenylmethylene)-5(4H)-isoxazolones and related compounds were designed and prepared as candidates for structurally novel androgen antagonists. Several compounds showed potent anti-androgenic activity as assessed by nuclear androgen receptor binding assay and growth inhibition assay using androgen-dependent Shionogi carcinoma cells SC-3. They were approximately 10-220 times more potent than flutamide in these assay systems. They also showed anti-androgenic activity toward prostate tumor cell line LNCaP, which has an aberrant nuclear androgen receptor.
- Ishioka, Toshiyasu,Kubo, Asako,Koiso, Yukiko,Nagasawa, Kazuo,Itai, Akiko,Hashimoto, Yuichi
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p. 1555 - 1566
(2007/10/03)
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- Bulk dyeing of plastics
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Bulk dyeing of plastics using dyestuffs of the formula (I) STR1 wherein n denotes 1 or 2, preferably 1, Ro for n=1, denotes aryl, hetaryl or heterocyclylidenemethyl, or for n=2, denotes a direct bond or arylene and the ring A is unsubstituted or substituted by C1 -C4 -alkyl, C5 -C8 -cycloalkyl, C6 -C10 -aryl, C1 -C4 -alkyloxy, C6 -C10 -aryloxy, C6 -C10 -aryl- or C1 -C4 -alkylsulphonyl, cyano, halogen, in particular chlorine or bromine, or a radical of the formula --COR1, wherein R1 represents C1 -C4 -alkoxy, amino, C1 -C4 -alkylamino, di-C1 -C4 -alkylamino, C6 -C10 -arylamino, C1 -C4 -alkyl or C6 -C10 -aryl, or contains a fused-on aromatic or cycloaliphatic ring, the plastics used being, in particular, thermoplastics, preferably vinyl polymers, polyesters or polyamides.
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- Photochromatic compound, a method for its preparation, and articles which contain it
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A photochromatic compound represented by the following general formula (I): STR1 where: R1 and R2 independently represent a linear, branched or cyclic C1-C10 alkyl radical, H, OH, F, Cl, Br, NH2, N(R4)2, COOH, OR4 or COOR4 where R4 is a C1-C10 linear, branched or cyclic alkyl radical, or an aryl radical; R3 is a variously substituted mono or polycondensed heterocyclic or aryl radical. A compound (I) demonstrates marked photochromatic characteristics both when in an organic solvent solution and when incorporated into polymer matrices.
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- Photochromatic compound, a method for its preparation, and articles which contain it
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A photochromatic compound represented by the following general formula (I): where:, R1 and R2 independently represent a linear, branched or cyclic C1-C10 alkyl radical, H, OH, F, Cl, Br, NH2, N(R4)2, COOH, OR4 or COOR4 where R4 is a C1-C10 linear, branched or cyclic alkyl radical, or an aryl radical;, R3 is a variously substituted mono or polycondensed heterocyclic or aryl radical. A compound (I) demonstrates marked photochromatic characteristics both when in an organic solvent solution and when incorporated into polymer matrices.
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- Process for nucleophilic fluoroalkylation of aldehydes
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Aryl difluoromethyl sulfone adds to alkehydes under phase transfer conditions to give novel substituted alcohols of the general formula wherein R is an aryl, cycloaliphatic, sec- or tert-aliphatic, or heterocyclic group and Ar is an aryl group. The substituted alcohols of formula I are of particular utility as intermediates in the synthesis of a variety of useful end products. For example, the products of formula I may be utilized in desulfonylation reactions, oxidation reactions and fluorination reactions.
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- Disazo triphenylamine compounds
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A disazo compound, having the general formula, STR1 wherein Y represents a substituted or non-substituted cyclic hydrocarbon or substituted or non-substituted heterocycle; R represents hydrogen, substituted or non-substituted alkyl group, or substituted or non-substituted phenyl group; and Z represents a substituted or non-substituted cyclic hydrocarbon or heterocycle fused with phenyl nucleus.
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- Antifungal composition and method employing pyridinium compounds
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Compounds containing a cation of formula Ia STR1 and a pharmaceutically acceptable anion are anti-fungal agents. In formula Ia and Ib R1 is alkyl of at least 3 carbon atoms or aralkyl; R2 and R5 are hydrogen, lower alkyl, lower alkoxy, halogen or nitro; R6 and R7, when separate, are lower alkyl or aryl(lower)alkyl or, when joined together, are --(CH2)2 --A--(CH2)2 -- (where A is --(CH2)n --, O, S or NR8 where n is O, 1 or 2 and R8 is lower alkyl) or a mono- or di-(lower alkyl) substitution product thereof.
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- 3-(substituted phenyl)phthalides
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Process comprises the combination of the three steps of condensing 3-N(R)2 -4-X-benzoic acid with an aromatic or heterocyclic aldehyde, Y-CHO, under acidic conditions to produce 3-Y-5-X-6-N(R)2 phthalide (II), condensing said phthalide with a compound of the formula Z-H under alkaline or acid conditions to produce 2-(α-Y-α-Z)methyl-4-X-5-N(R)2 benzoic acid (III), and oxidizing said benzoic acid to produce 3-Y-3-Z-5-X-6-N(R)2 phthalide (I) where: R is hydrogen, non-tertiary alkyl of one to four carbon atoms, benzyl or substituted benzyl; X is hydrogen or halo; Y is 4-R1 -3-R2 -2-R1 -phenyl, 1-R5 -2-R6 -5/6-R4 -3-indolyl, 9-R7 -3-carbazolyl, 9-julolidinyl, 3,4-dioxymethylenephenyl, 2-thienyl, 1-R8 -2-pyrrolyl, or 4-pyridinyl; and Z is 4-R1 -3-R2 -2-R1 -phenyl, 1-R5 -2-R6 -5/6-R4 -3-indolyl or 1-R8 -2-pyrrolyl which are useful as colorless precursor color formers in carbonless duplicating and in thermal marking systems. The intermediates, 3-Y-5-X-6-N(R)2 phthalides (II) and 2-(α-Y-α-Z)methyl-4-X-5-N(R)2 benzoic acids (III) also have utility as colorless precursor color formers in carbonless duplicating and thermal marking systems.
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- Process for the preparation of cationic methine dyestuffs
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Methine dyestuffs of the formula STR1 are prepared by subjecting a compound STR2 to a condensation reaction with a compound and with 1 to 5 equivalents of an inorganic acid in the presence of 0-30% by weight of an organic solvent and 0-15% by weight of water.
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- Preparation of cationic methine dyestuffs
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A method of preparation of cationic dyestuffs having the formula STR1 wherein A, B, R, and R1 are defined in the specification carried out in the substantial absence of solvent and removing water formed in the reaction.
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- Novel compounds, processes and marking systems
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Mono and bis substituted (arylsulfonyl)alkanes useful as color formers, particularly in carbonless duplicating and thermal marking systems, are prepared by the interaction of the appropriate aldehyde or dialdehyde with the appropriate aryl or heterocyclic moiety and the appropriate phenylsulfinic acid in the presence of a catalyst.
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