- Discovery of Atabecestat (JNJ-54861911): A Thiazine-Based β-Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor Advanced to the Phase 2b/3 EARLY Clinical Trial
-
Accumulation of amyloid β peptides (Aβ) is thought to be one of the causal factors of Alzheimer's disease (AD). The aspartyl protease β-site amyloid precursor protein cleaving enzyme 1 (BACE1) is the rate-limiting protease for Aβ production, and therefore
- Koriyama, Yuji,Hori, Akihiro,Ito, Hisanori,Yonezawa, Shuji,Baba, Yoshiyasu,Tanimoto, Norihiko,Ueno, Tatsuhiko,Yamamoto, Shiho,Yamamoto, Takahiko,Asada, Naoya,Morimoto, Kenji,Einaru, Shunsuke,Sakai, Katsunori,Kanazu, Takushi,Matsuda, Akihiro,Yamaguchi, Yoshitaka,Oguma, Takuya,Timmers, Maarten,Tritsmans, Luc,Kusakabe, Ken-Ichi,Kato, Akira,Sakaguchi, Gaku
-
p. 1873 - 1888
(2021/03/01)
-
- SULFUR-CONTAINING HETEROCYCLIC DERIVATIVE HAVING ?-SECRETASE-INHIBITING ACTIVITY
-
The following compound is provided as an agent for treating a disease induced by production, secretion and/or deposition of amyloid β protein, for example,. a compound represented by the formula (I): wherein ruing A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group, R1 is optionally substituted lower alkyl or the like, R2a and R2b are each independently hydrogen, optionally substituted lower alkyl or the like, R3a and R3c are each independently hydrogen, halogen, hydroxy, optionally substituted lower alkyl or the like, or a pharmaceutically acceptable salt thereof, or a solvate thereof.
- -
-
Page/Page column 96
(2011/04/25)
-