A practical synthesis of b-keto thioesters by direct crossed-claisen coupling of thioesters and N-acylbenzotriazoles
Thioesters undergo chemoselective soft enolization and acylation with N-acylbenzotriazoles on treatment with MgBr2?OEt2 and i-Pr2NEt to give b-keto thioesters. Prior enolate formation is not required and the reaction is conducted using untreated dichlorom
Zhou, Guoqiang,Lim, Daniel,Fang, Fang,Coltart, Don M.
experimental part
p. 3350 - 3352
(2010/03/03)
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