Palladium-catalyzed regioselective oxidative coupling of indoles and one-pot synthesis of acetoxylated biindolyls
(Chemical Equation Presented) Mild conditions have been developed to achieve Pd-catalyzed homocoupling of indoles with excellent regioselectivity in the presence of Cu(OAc)2·H2O in DMSO at room temperature in high efficiency. This method provides a simple route to 2,3′-biindolyls from the electron-rich to moderately electron-poor indoles. The reaction tolerates the bromide substituent on indoles. In addition, a one-pot approach to C3-position acetoxylated biindolyls is realized via palladium catalysis by the use of AgOAc under oxygen atmosphere as oxidants. 2009 American Chemical Society.
Liang, Zunjun,Zhao, Jinlong,Zhang, Yuhong
supporting information; experimental part
p. 170 - 177
(2010/04/04)
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