Reversal agent and linker variants of reversed chloroquines: Activities against Plasmodium falciparum
We have shown that "reversed chloroquine molecules" constructed from chloroquine-like and resistance "reversal-agent"-like cores can be powerful drugs against malaria (J. Med. Chem. 2006, 49, 5623-5625). Several reversed chloroquines are now presented that probe parameters governing the activities against chloroquine-resistant and chloroquine-sensitive malaria strains. The design is tolerant to linker and reversal agent changes, but a piperazinyl group adjacent to the quinoline, at least for the group of compounds studied here, may be detrimental. 2009 American Chemical Society.
Andrews, Simeon,Burgess, Steven J.,Skaalrud, Deborah,Kelly, Jane Xu,Peyton, David H.
supporting information; experimental part
p. 916 - 919
(2010/07/05)
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