1202055-34-2 Usage
Uses
Used in Pharmaceutical Industry:
NMS-P715 is used as a targeted therapy agent for cancer treatment. It is employed to inhibit the activity of the protein kinase MPS1, which is crucial for accurate cell division. By preventing MPS1 activity, NMS-P715 disrupts spindle assembly checkpoints and causes inaccurate chromosomal segregation, leading to the death of tumor cells. This targeted approach can be particularly effective in treating cancers where traditional chemotherapy and radiotherapy may have limited efficacy or cause severe side effects.
Check Digit Verification of cas no
The CAS Registry Mumber 1202055-34-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,0,2,0,5 and 5 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1202055-34:
(9*1)+(8*2)+(7*0)+(6*2)+(5*0)+(4*5)+(3*5)+(2*3)+(1*4)=82
82 % 10 = 2
So 1202055-34-2 is a valid CAS Registry Number.
1202055-34-2Relevant articles and documents
Synthesis and SAR of new pyrazolo[4,3-h]quinazoline-3-carboxamide derivatives as potent and selective MPS1 kinase inhibitors
Caldarelli, Marina,Angiolini, Mauro,Disingrini, Teresa,Donati, Daniele,Guanci, Marco,Nuvoloni, Stefano,Posteri, Helena,Quartieri, Francesca,Silvagni, Marco,Colombo, Riccardo
, p. 4507 - 4511 (2011/09/12)
The synthesis and SAR of a series of novel pyrazolo-quinazolines as potent and selective MPS1 inhibitors are reported. We describe the optimization of the initial hit, identified by screening the internal library collection, into an orally available, potent and selective MPS1 inhibitor.
