- FLUORESCENT MOLECULE AND METHOD FOR DETECTING TARGET NUCLEIC ACID
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Provided are a fluorescent on/off switchable compound for a gene analysis, which is highly stable and highly sensitive, and enables amplification and observation of a trace gene signal, and a labeling reagent for detection of a bio-related material, which uses the fluorescent on/off switchable compound. A compound represented by the following formula (I'): wherein X is a hydrogen atom or a carboxylic acid-protecting group, Y is a 2,4-dinitrobenzenesulfonyl group, a 2-cyano-4-nitrobenzenesulfonyl group or a 5-nitropyridin-2-ylsulfonyl group, R1, R2, R3 and R4 are each independently a hydrogen atom, a halogen atom, a hydroxyl group, an alkyl group having a carbon number of 1 to 6, an alkoxy group having a carbon number of 1 to 6, an aryl group having a carbon number of 6 to 10, or a cyano group.
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Page/Page column 10
(2012/08/14)
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- DNA templated nucleophilic aromatic substitution reactions for fluorogenic sensing of oligonucleotides
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We have developed an SNAr reaction-triggered fluorescence probe using a new fluorogenic compound derivatized from 7-aminocoumarin for oligonucleotides detection. The Royal Society of Chemistry 2009.
- Shibata, Aya,Abe, Hiroshi,Ito, Mika,Kondo, Yuko,Shimizu, Shigeru,Aikawa, Kyoko,Ito, Yoshihiro
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supporting information; experimental part
p. 6586 - 6588
(2010/04/01)
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