Short Synthesis of 1-(3-tert-Butyl-1-phenyl-1H-pyrazol-5-yl)-3-(5-(2- morpholinoethoxy)-2H-chromen-8-yl) urea derivatives
A short and efficient synthesis of 1-(3-tert-butyl-1-phenyl-1H-pyrazol-5- yl)-3-(5-(2-morpholinoethoxy)-2H-chromen-8-yl) urea derivatives (1a-c), a novel type of p38 MAPK inhibitors, is described. The Claisen thermal rearrangement of arylpropargyl ethers
Li, Xingzhou,Zhou, Xinming,Zheng, Zhibing,Zhong, Wu,Xiao, Junhai,Li, Song