120279-20-1

Basic information

• Product Name: 3-(2-THIENYLTHIO)BUTANOIC ACID
• Synonyms: 3-(2-THIENYLTHIO)BUTANOIC ACID;3-(2-Thienylthio)butyric acid
• CAS NO: 120279-20-1
• Molecular Formula: C₈H₁₀O₂S₂
• Molecular Weight: 202.29
• Mol File: 120279-20-1.mol

Chemical Properties

• Boiling Point: 168 °C(Press: 14 Torr)
• Appearance: /
• Density: 1.30±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 4.25±0.10(Predicted)
• CAS DataBase Reference: 3-(2-THIENYLTHIO)BUTANOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-THIENYLTHIO)BUTANOIC ACID(120279-20-1)
• EPA Substance Registry System: 3-(2-THIENYLTHIO)BUTANOIC ACID(120279-20-1)

Safety Data

• Hazardous Substances Data: 120279-20-1(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
3-(2-Thienylthio)butanoic acid is used as a key intermediate in the synthesis of various organic compounds due to its reactive thienylthio group. Its presence allows for the formation of new chemical bonds and the creation of diverse molecular structures, contributing to the advancement of organic chemistry.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 3-(2-Thienylthio)butanoic acid is utilized as a starting material for the development of new drugs. Its unique structure and potential biological activity make it an attractive target for the design and synthesis of novel therapeutic agents. Researchers can explore its interactions with biological targets and evaluate its efficacy in treating various diseases.
Used in Medicinal Chemistry:
3-(2-Thienylthio)butanoic acid is employed as a versatile building block in medicinal chemistry for the design and optimization of drug candidates. Its sulfur-containing nature and the presence of the thienylthio group provide opportunities for structure-activity relationship studies, enabling chemists to fine-tune the properties of drug molecules and improve their pharmacological profiles.

Upstream product

• 107-93-7 (E)-but-2-enoic acid 
• 7774-74-5 Thiophene-2-thiol 

Downstream Products

• 120279-85-8 5,6-Dihydro-4H-6-methylthieno[2,3-b]thiopyran-4-one 
• 1197375-23-7 D-(+)-methylbenzylamine (3S)-3-(2-thienylthio)butyrate salt 

Relevant articles and documents

PROCESS FOR PREPARING DORZOLAMIDE HYDROCHLORIDE AND ITS INTERMEDIATE

The present invention relates to an improved process for the preparation of (4S,6S)-4- (ethylamino)-5,6-dihydro-6-methyl-4H-thieno[2,3-b]thiopyran-2-sulfonamide-7,7-dioxide hydrochloride ("Dorzolamide hydrochloride") having formula 1. Dorzolamide hydrochloride is prepared by the process of the present invention with high chemical and diastereomeric purity. The present invention also relates to novel intermediate of the formula 20 and a process for its preparation. Dorzolamide hydrochloride is useful in the treatment of ocular hypertension by inhibiting carbonic anhydrase enzyme.

Process for the preparation of 6-substituted-4-oxo-thieno [2,3b]thiopyran-2-sulfonic acid

The present invention relates to one-pot process for the preparation of 6-substituted-4-oxo-thieno[2,3b]thiopyran-2-sulfonic acid of formula (I), which comprises, reacting 2-thienylthiol with alkenyl acid in the presence of an aromatic hydrocarbon solvent and a base, cyclization of the resulting compound and further reacting with an acid anhydride and sulfuric acid to get the desired compound of formula (I). The compound of formula (I) is the key intermediate in the preparation of (S,S)-5,6-dihydro-4-alkyylamino-6-substituted-4H-thieno[2,3-b]thiopyran-2-sulfonamide-7,7-dioxide and analogs thereof.

Process for preparing 5,6-dihydro-4-(S)-(ethylamino)-6-(S) methyl-4H-thieno[2,3b]thiopyran-2-sulphonamide-7,7-dioxide HCI

The present invention relates to an improved process for the preparation of 5,6-dihydro-4-(S)-(ethylamino)-6-(S)methyl-4H-thieno[2,3b]thiopyran-2-sulphonamide-7,7-dioxide hydrochloride of formula (I) commonly known as Dorzolamide Hydrochloride useful as an agent to reduce intraoccular pressure by inhibiting carbonic anhydrase enzyme

PROCESS FOR PREPARING 5,6-DIHYDRO-4-(S)-(ETHYLAMINO)-6-(S) METHYL-4H-THIENO[2,3b]THIOPYRAN-2-SULPHONAMIDE-7,7-DIOXIDE HCI

The present invention relates to an improved process for the preparation of 5,6-dihydro-4-(S)-(ethylamino)-6-(S)methyl-4H-thieno[2,3b]thiopyran-2-sulphonamide-7,7-dioxide hydrochloride of formula (I) commonly known as Dorzolamide Hydrochloride useful as an agent to reduce intraoccular pressure by inhibiting carbonic anhydrase enzyme.

Process for preparing carboxylic acid derivative

There is described a process for preparing 3-(2-thienylthio)butyric acid by converting a compound having the formula (III): STR1 wherein R is a straight chain or branched C 1 to C 4 alkyl group, whereby the production of 3-(3-thienylthio)butyric acid as a by-product which is the position isomer can be controlled to at most 0.1 mol %. 3-(2-Thienylthio)butyric acid is a useful compound as an intermediate for a medicinal compound.