Synthesis and antitumor-evaluation of cyclopropyl-containing combretastatin analogs
Several derivatives of combretastatin have been prepared bearing a cyclopropyl unit instead of the natural occurring cis-double bond. Final products and synthetic intermediates were evaluated for their cytotoxic properties in two human cancer cell lines.
Fuerst, Rita,Zupko, Istvan,Berenyi, Agnes,Ecker, Gerhard F.,Rinner, Uwe