- Kumadatamaocorriu coupling of alkyl halides catalyzed by an ironbisphosphine complex
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An iron(II) chloride complex possessing a sterically demanding ortho-phenylene-tethered bisphosphine ligand shows a high catalytic activity in the KumadaTamaoCorriu coupling of nonactivated alkyl halides with aryl Grignard reagents. Primary, secondary, and tertiary alkyl halides can participate as an electrophilic coupling partner. A radical clock experiment using (iodomethyl)cyclopropane exclusively gives the corresponding ring-opening coupling product, suggesting intermediacy of alkyl radical species.
- Hatakeyama, Takuji,Fujiwara, Yu-Ichi,Okada, Yoshihiro,Itoh, Takuma,Hashimoto, Toru,Kawamura, Shintaro,Ogata, Kazuki,Takaya, Hikaru,Nakamura, Masaharu
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p. 1030 - 1032
(2011/12/05)
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- CATALYST FOR CROSS-COUPLING REACTION, AND PROCESS FOR PRODUCTION OF AROMATIC COMPOUND USING THE SAME
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The present invention provides a process for efficiently producing an alkylated aromatic compound in good yield, by a cross-coupling reaction between an alkyl halide and an aromatic magnesium reagent. A process for producing an aromatic compound represented by Formula (1): [in-line-formulae]R—Ar′??(1)[/in-line-formulae]wherein R is a hydrocarbon group, and Ar′ is an aryl group;the process comprising:reacting a compound represented by Formula (2): [in-line-formulae]R—X??(2)[/in-line-formulae]wherein X is a halogen atom, and R is as defined above, with a magnesium reagent represented by Formula (3): [in-line-formulae]Ar′—MgY??(3)[/in-line-formulae]wherein Y is a halogen atom, and Ar′ is as defined above, in the presence of a catalyst for cross-coupling reactions comprising an iron compound and a bisphosphine compound represented by Formula (4): wherein Q is a divalent group derived from an aromatic ring by removing two hydrogen (H) atoms on adjacent carbon atoms; and each Ar is independently an aryl group.
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Page/Page column 15
(2011/07/06)
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- Iron-catalyzed Suzuki-Miyaura coupling of alkyl halides
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In the presence of novel iron(II) chloride-diphosphine complexes and magnesium bromide, lithium arylborates react with primary and secondary alkyl halides to give the corresponding coupling products in good to excellent yields. High functional group compa
- Hatakeyama, Takuji,Hashimoto, Toru,Kondo, Yoshiyuki,Fujiwara, Yuichi,Seike, Hirofumi,Takaya, Hikaru,Tamada, Yoshinori,Ono, Teruo,Nakamura, Masaharu
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p. 10674 - 10676
(2010/11/04)
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