A novel class of 3-(phenoxy-phenyl-methyl)-pyrrolidines as potent and balanced norepinephrine and serotonin reuptake inhibitors: Synthesis and structure-activity relationships
A series of 3-(phenoxy-phenyl-methyl)-pyrrolidine analogues were discovered to be potent and balanced norepinephrine (NE) and serotonin (5-hydroxytryptamine, 5-HT) reuptake inhibitors. Several of these compounds were identified to have suitable in vitro p
Van Orden, Lori Jean,Van Dyke, Priscilla M.,Saito, D. Roland,Church, Timothy J.,Chang, Ray,Smith, Jacqueline A.M.,Martin, William J.,Jaw-Tsai, Sarah,Stangeland, Eric L.
supporting information
p. 1456 - 1461
(2013/03/14)
3-(PHENOXYPHENYLMETHYL)PYRROLIDINE COMPOUNDS
In one aspect, the invention relates to compounds of formula I: where a and R1-6 are as defined in the specification, or a pharmaceutically acceptable salt thereof. The compounds of formula I are serotonin and norepinephrine reuptake inhibitors
-
Page/Page column 49
(2010/02/17)
More Articles about upstream products of 1204672-59-2