- Palladium-catalyzed decarbonylative C–N coupling to convert arylcarbamoyl chlorides to urea derivatives
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This paper describes the development of a palladium-catalyzed decarbonylative C–N coupling reaction that transforms arylcarbamoyl chlorides into tetrasubstituted ureas under a nitrogen atmosphere. A broad range of functional groups are compatible with this reaction, and diverse urea derivatives can be obtained with good to high yields.
- Fan, Aihong,Peng, Jinsong,Zhou, Dun,Li, Xiang,Chen, Chunxia
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supporting information
p. 1 - 12
(2020/07/27)
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- Conformation and stereodynamics of 2,2′-disubstituted N,N′-diaryl ureas
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Except in the most hindered of cases, N,N′-diaryl N,N′-dimethyl ureas adopt a conformation with the two aryl rings disposed cis to one another. Variable temperature NMR studies reveal the rate at which the Ar-N bonds rotate as well as the conformational preference of ortho disubstituted ureas in which more than one cis orientation is possible. In general, a conformation in which the aryl rings lie close in space but with their most bulky 2-substituents aligned anti is preferred, but with particularly bulky 2-substituents, conformations in which one of the aryl rings points away from the other may also be populated. The Royal Society of Chemistry.
- Clayden, Jonathan,Lemiegre, Loic,Pickworth, Mark,Jones, Lyn
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supporting information; experimental part
p. 2908 - 2913
(2009/02/02)
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