120570-48-1

Basic information

• Product Name: 4-THIAZOLEACETIC ACID, 2-AMINO-ALPHA-(HYDROXYIMINO)
• Synonyms: 4-THIAZOLEACETIC ACID, 2-AMINO-ALPHA-(HYDROXYIMINO);2-(2-amino-1,3-thiazolyl-4-yl)-2-hydroxyiminoacetic acid;4-THIAZOLEACETICACID,2-AMINO-A-(HYDROXYIMINO);4-Thiazoleacetic acid, 2-amino-α-(hydroxyimino)-;2-Athiaa;2-(2-AMinothiazol-4-yl)-2-(hydroxyiMino)acetic acid
• CAS NO: 120570-48-1
• Molecular Formula: C₅H₅N₃O₃S
• Molecular Weight: 187.18
• Mol File: 120570-48-1.mol

Chemical Properties

• Boiling Point: 539.4 °C at 760 mmHg
• Flash Point: 280 °C
• Appearance: /
• Density: 1.92 g/cm³
• Vapor Pressure: 1.82E-12mmHg at 25°C
• Refractive Index: 1.798
• PKA: 2.10±0.10(Predicted)
• CAS DataBase Reference: 4-THIAZOLEACETIC ACID, 2-AMINO-ALPHA-(HYDROXYIMINO)(CAS DataBase Reference)
• NIST Chemistry Reference: 4-THIAZOLEACETIC ACID, 2-AMINO-ALPHA-(HYDROXYIMINO)(120570-48-1)
• EPA Substance Registry System: 4-THIAZOLEACETIC ACID, 2-AMINO-ALPHA-(HYDROXYIMINO)(120570-48-1)

Safety Data

• Hazardous Substances Data: 120570-48-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-Thiazoleacetic acid, 2-amino-alpha-(hydroxyimino) is utilized as an active pharmaceutical ingredient for its potential antibacterial properties, offering a new avenue for combating bacterial infections. Its unique structure allows it to target specific bacterial mechanisms, potentially leading to the development of novel antibiotics.
Used in Agrochemical Industry:
In the agrochemical sector, 4-Thiazoleacetic acid, 2-amino-alpha-(hydroxyimino) serves as a key intermediate in the synthesis of various compounds. Its incorporation into these products can enhance their effectiveness in controlling pests and diseases in agriculture, thereby contributing to increased crop yields and food security.
Used in Cancer Treatment Research:
4-THIAZOLEACETIC ACID, 2-AMINO-ALPHA-(HYDROXYIMINO) is also being investigated for its potential role in cancer treatment. Studies are exploring its ability to target and inhibit the growth of cancer cells, offering a new therapeutic approach for various types of cancer. Its unique chemical structure may allow for selective action against cancerous cells, minimizing damage to healthy tissues.
Used in Inflammatory Disease Management:
4-Thiazoleacetic acid, 2-amino-alpha-(hydroxyimino) has shown promise in the management of inflammatory diseases. Its potential to modulate inflammatory responses could lead to the development of new treatments for conditions such as arthritis, asthma, and other autoimmune disorders, improving the quality of life for affected individuals.

InChI:InChI=1/C5H5N3O3S/c6-5-7-2(1-12-5)3(8-11)4(9)10/h1,11H,(H2,6,7)(H,9,10)/b8-3-

Upstream product

• 60845-81-0 ethyl 2-amino-α-(hydroxyimino)-4-thiazole acetate 

Downstream Products

• 914358-45-5 syn-2-(2-aminothiazol-4-yl)-2-(methylcarbonyloxyimino)-acetic acid 

Relevant articles and documents

Preparation method of aminothiazole acetyloxime acid with controllable particle size

The invention relates to a preparation method of aminothiazole acetyloxime acid with a controllable particle size, and belongs to the technical field of chemical pharmacy. The preparation method comprises the following steps: ahydrolysis step: hydrolyzing ethyl 2-(2-aminothiazole-4-yl)-2-hydroxyiminoacetate serving as a raw material to generate a compound 1; an acylation step: dropwisely adding an acylating agent into the system to perform acylation reaction to obtain a compound 2; and a crystallization step: adding activated carbon into the reaction system for decolorization, then dropwise adding an acidic solution into the system at different temperatures to control the pH value of the system, and after the solid is separated out, carrying out centrifugal drying to obtain a compound 3 with controllable particle size. According to the method, by controlling different acid liquor adding temperatures, the particle size of the prepared aminothiazole acetyloxime acid is controllable; and the technological process is simple to operate and suitable for industrial production.

4-Carbamoyloxymethyl-1-sulfo-2-oxoazetidine derivatives and their production

Disclosed are compounds of the general formula: STR1 wherein R1 is a hydrogen atom or a lower alkyl group and R2 is a hydrogen atom or an ester residue, said derivative having the (3S,4S)-configuration; and pharmaceutically acceptable salts and esters thereof. The compounds have antimicrobial and/or β-lactamase-inhibitory activity and are of value as drugs for human beings and domesticated animals.