120583-62-2

Basic information

• Product Name: Mammoside J
• Synonyms: (11S)-11-[[2-O-[4-O-(4-O-α-L-Rhamnopyranosyl-3-O-β-D-glucopyranosyl-α-L-rhamnopyranosyl)-α-L-rhamnopyranosyl]-β-D-fucopyranosyl]oxy]hexadecanoic acid;Mammoside J;Operculinic acid A
• CAS NO: 120583-62-2
• Molecular Formula: C₄₆H₈₂O₂₄
• Molecular Weight: 1019.12888
• Mol File: 120583-62-2.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Mammoside J(CAS DataBase Reference)
• NIST Chemistry Reference: Mammoside J(120583-62-2)
• EPA Substance Registry System: Mammoside J(120583-62-2)

Safety Data

• Hazardous Substances Data: 120583-62-2(Hazardous Substances Data)

Upstream product

• 1137099-34-3 batatoside I 
• 1137099-32-1 batatoside H 

Relevant articles and documents

Resin glycosides from Ipomoea wolcottiana as modulators of the multidrug resistance phenotype in vitro

Recycling liquid chromatography was used for the isolation and purification of resin glycosides from the CHCl3-soluble extracts prepared using flowers of Ipomoea wolcottiana Rose var. wolcottiana. Bioassay-guided fractionation, using modulation of both antibiotic activity against multidrug-resistant strains of Gram-negative bacteria and vinblastine susceptibility in breast carcinoma cells, was used to isolate the active glycolipids as modulators of the multidrug resistance phenotype. An ester-type dimer, wolcottine I, one tetra- and three pentasaccharides, wolcottinosides I-IV, in addition to the known intrapilosin VII, were characterized by NMR spectroscopy and mass spectrometry. In vitro assays established that none of these metabolites displayed antibacterial activity (MIC > 512 μg/mL) against multidrug-resistant strains of Escherichia coli, and two nosocomial pathogens: Salmonella enterica serovar Typhi and Shigella flexneri; however, when tested (25 μg/mL) in combination with tetracycline, kanamycin or chloramphenicol, they exerted a potentiation effect of the antibiotic susceptibility up to eightfold (64 μg/mL from 512 μg/mL). It was also determined that these non-cytotoxic (CI50 > 8.68 μM) agents modulated vinblastine susceptibility at 25 μg/mL in MFC-7/Vin+ cells with a reversal factor (RFMCF-7/Vin+) of 2-130 fold.

Two pentasaccharide resin glycosides from Argyreia acuta

Two new compounds of acutacosides 1 and 2, pentasaccharide resin glycosides were isolated from the aerial parts of Argyreia acuta. The core of the two compounds was operculinic acid A, and they were esterfied at the same position, just one substituent group was linked at C-2 of Rha. The absolute configuration of the aglycone in the two compounds was established by Mosher's method, which was (11S)-hydroxyhexadecanoic acid (jalapinolic acid). Their structures were established by a combination of spectroscopic and chemical methods.

Novel acylated lipo-oligosaccharides from the tubers of Ipomoea batatas

Nine new lipo-oligosaccharides, batatosides H-P, were isolated from the tubers of Ipomoea batatas (Convolvulaceae). Spectral and chemical methods allowed to characterize them as tetra- or penta-saccharides that form a macrolactone with the aglycone, (11S)