- OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF
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The present disclosure provides modified oligonucleotides and compositions and methods thereof. In some embodiments, provided technologies comprise modified sugars and/or modified internucleotidic linkages. In some embodiments, the present disclosure provides technologies for preparing modified oligonucleotides. In some embodiments, the present disclosure provides chirally controlled oligonucleotide compositions and methods for their preparation and uses.
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- New acyclonucleosides: Synthesis and anti-HIV activity
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The synthesis of new acyclic nucleosides is described. These syntheses were accomplished by various methods: glycosylation, selective or total deprotection, oxidation/reduction, chlorination or azidation of hydroxyl groups. The compounds were characterized with NMR, mass and IR spectroscopy. Antiviral properties of these compounds were evaluated on HIV-1 infected cell lines. Copyright Taylor & Francis, Inc.
- Hadj-Bouazza, Amel,Zerrouki, Rachida,Krausz, Pierre,Laumond, Geraldine,Aubertin, Anne Marie,Champavier, Yves
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p. 1249 - 1263
(2007/10/03)
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- 2'-Azido-2',3'-dideoxypyrimidine nucleosides. Synthesis and antiviral activity against human immunodeficiency virus
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A series of four 2'-azido-2',3'-dideoxypyrimidine nucleosides were synthesized and their activity against human immunodeficiency virus was explored. 2,2'-Anhydro-5-O-benzoyluridine (6a) was prepared from 5-O-benzoyluridine (5a) and converted into 3'-deoxy
- Warshaw,Watanabe
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p. 1663 - 1666
(2007/10/02)
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- The chemistry of 2′,3′-seconucleosides IV. Synthesis and reactions of 3′-azido-2′,3′-dideoxy-2′,3′- secothymidine and related analogues
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The synthesis of a series of 2,3-seconucleoside analogues related to nucleosides previously shown to possess anti-HIV activity is described. Using strategies to distinguish between the three primary hydroxyl groups of a 2,3-seconucleoside, 3-azido-2,3-dideoxy-2,3-secothymidine and 2,3-dideoxy-2,3-secothymidine have been prepared. These compounds, several of the intermediates in their synthesis, as well as O22-anhydro-3-azido-3-deoxy-2,3-secothymidine and several 2,3-secouridine analogues have been tested for their ability to prevent infection of cells by HIV. None showed any significant toxicity or antiviral activity.
- Kumar, Ajit,Walker, Richard T.
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p. 3101 - 3110
(2007/10/02)
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