Total synthesis and biological evaluation of a series of macrocyclic hybrids and analogues of the antimitotic natural products dictyostatin, discodermolide, and taxol
The design, synthesis, and biological evaluation of a series of hybrids and analogues of the microtubule-stabilizing anticancer agents dictyostatin, discodermolide, and taxol is described. A 22-membered macrolide scaffold was prepared by adapting earlier
Paterson, Ian,Naylor, Guy J.,Gardner, Nicola M.,Guzman, Esther,Wright, Amy E.
p. 459 - 473
(2011/10/12)
Total synthesis of a library of designed hybrids of the microtubule-stabilising anticancer agents taxol, discodermolide and dictyostatin
A hybrid library of the marine natural products dictyostatin and discodermolide, incorporating the taxol or taxotere side chains, were synthesised; preliminary biological evaluation in the PANC-1 cancer cell line revealed significant antiproliferative activity, demonstrating that a macrolide scaffold is an effective surrogate for the baccatin core of taxol.
Paterson, Ian,Naylor, Guy J.,Fujita, Takeshi,Guzman, Esther,Wright, Amy E.
supporting information; experimental part
p. 261 - 263
(2010/05/01)
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