Annulation of thioimidates and vinyl carbodiimides to prepare 2-aminopyrimidines, competent nucleophiles for intramolecular alkyne hydroamination. Synthesis of (-)-crambidine
(Chemical Presented) A convergent synthesis of (-)-crambidine is reported. The sequence capitalizes on two novel key transformations, including a [4+2] annulation of thioimidates with vinyl carbodiimides and an alkyne hydroamination employing 2-aminopyrimidine nucleophiles. Copyright
Perl, Nicholas R.,Ide, Nathan D.,Prajapati, Sudeep,Perfect, Hahdi H.,Duron, Sergio G.,Gin, David Y.
supporting information; experimental part
p. 1802 - 1803
(2010/04/24)
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