Efficient Pd(ii)-catalyzed regioselectiveortho-halogenation of arylcyanamides
Regioselectiveortho-halogenation of arylcyanamides using a Pd(ii) catalyst has been established under mild reaction conditions. Either electron-donating or electron-withdrawing groups readily carried out the reaction and produced final products in moderate to good yields. Based on the experimental work, we have confirmed that this method does not undergo a free radical mechanism. Furthermore, we have also attempted this method for practical utility purposes.
Alam, M. Mujahid,Boddapati, S. N. M.,Bollikolla, Hari Babu,Gugulothu, Sailaja,Tamminana, Ramana,Varala, Ravi
supporting information
p. 17176 - 17182
(2021/10/04)
Environmentally benign one-pot synthesis of cyanamides from dithiocarbamates using I2 and H2O2
An environmentally benign reaction is devised for the synthesis of cyanamides from dithiocarbamate salts using iodine and H2O 2. Taylor & Francis Group, LLC.
Jamir, Latonglila,Sinha, Upasana Bora,Nath, Jayashree,Patel, Bhisma K.
p. 951 - 958
(2012/02/01)
Copper-catalyzed domino one-pot synthesis of 2-(arylselanyl)arylcyanamides
Domino C-Se cross-coupling of 2-(iodoaryl)selenoureas with aryl iodides has been accomplished in the presence of a copper(I)-1,1-phenanthroline complex at moderate temperature. The reactions involve intra- and intermolecular C-Se cross-coupling to give th
Ramana, Tamminana,Punniyamurthy, Tharmalingam
body text
p. 4756 - 4759
(2011/10/09)
Copper(I)-catalyzed cascade synthesis of 2-arylsulfanyl-arylcyanamides
We have developed a ligand-assisted copper(I)-catalyzed two sequential heteroarylation sequence. An intramolecular S-arylation is followed by an intermolecular N-arylation leading to the direct synthesis of N-aryl-2-aminobenzothiazoles. In most cases however, the 2-arylsulfanyl- arylcyanamide was the major product obtained via an intramolecular C-S bond formation, associated with C-S bond breakage, followed by an intermolecular S-arylation. The selectivity of this ligand-assisted reaction is quite different as compared to that of ligand-free reactions and the rates are much faster giving good yields of products. Various cyanamides can be prepared in excellent yields from their corresponding 1-substituted thioureas with or without the assistance of a ligand with a catalytic quantity of copper(I).
Sahoo, Santosh K.,Jamir, Latonglila,Guin, Srimanta,Patel, Bhisma K.
experimental part
p. 2538 - 2548
(2010/12/29)
A one-pot preparation of cyanamide from dithiocarbamate using molecular iodine
An efficient one-pot method for the synthesis of cyanamides from dithiocarbamate salts via a double desulfurization strategy using molecular iodine is disclosed. Dithiocarbamates, by the action of iodine yield isothiocyanates in situ, which on treatment with aqueous NH3 give thioureas. The thioureas so generated undergo further oxidative desulfurization with I2 giving corresponding cyanamides in good yields. Environmental benignity, cost effectiveness and high yields are the important attributes of this one pot procedure. The Royal Society of Chemistry 2009.