120811-32-7

Basic information

• Product Name: 2H-PYRAN-3-AMINE, TETRAHYDRO-
• Synonyms: CBI-BB ZERO/004809;2H-PYRAN-3-AMINE, TETRAHYDRO-;TETRAHYDRO-PYRAN-3-YLAMINE;Tetrahydro-2H-pyran-3-amine hydrochloride;Albb-005268;tetrahydro-2H-pyran-3-amine(SALTDATA: HCl);oxan-3-aMine;Tetrahydro-2H-pyran-3-aMine HCl
• CAS NO: 120811-32-7
• Molecular Formula: C₅H₁₁NO
• Molecular Weight: 101.15
• Mol File: 120811-32-7.mol

Chemical Properties

• Boiling Point: 151.357 °C at 760 mmHg
• Flash Point: 49.266 °C
• Appearance: /
• Density: 0.963 g/cm³
• Vapor Pressure: 3.68mmHg at 25°C
• Refractive Index: 1.449
• PKA: 9.97±0.20(Predicted)
• CAS DataBase Reference: 2H-PYRAN-3-AMINE, TETRAHYDRO-(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-PYRAN-3-AMINE, TETRAHYDRO-(120811-32-7)
• EPA Substance Registry System: 2H-PYRAN-3-AMINE, TETRAHYDRO-(120811-32-7)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39
• HazardClass: IRRITANT
• Hazardous Substances Data: 120811-32-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2H-PYRAN-3-AMINE, TETRAHYDROis used as a key intermediate in the synthesis of various pharmaceuticals for its ability to form diverse chemical structures and exhibit biological activity. Its presence in drug molecules can contribute to their therapeutic effects and pharmacological properties.
Used in Agrochemical Industry:
In the agrochemical industry, 2H-PYRAN-3-AMINE, TETRAHYDROis utilized as a precursor in the development of agrochemicals, such as pesticides and herbicides. Its reactivity allows for the creation of compounds with specific target activities, enhancing crop protection and yield.
Used in Organic Synthesis:
2H-PYRAN-3-AMINE, TETRAHYDROserves as a versatile building block in organic synthesis, enabling the construction of complex organic molecules with potential applications in various fields, including materials science, fragrances, and dyes.
Used in Medicinal Chemistry:
In medicinal chemistry, 2H-PYRAN-3-AMINE, TETRAHYDROis employed as a structural component in the design and synthesis of new drug candidates. Its unique properties and reactivity contribute to the discovery of novel therapeutic agents with improved efficacy and selectivity.

InChI:InChI=1/C5H11NO/c6-5-2-1-3-7-4-5/h5H,1-4,6H2

Upstream product

• 110-87-2 3,4-dihydro-2H-pyran 

Downstream Products

• 1315497-06-3 C₁₈H₁₈N₄O₅S 
• 1393176-37-8 N-(tetrahydropyran-3-yl)benzene-1,2-diamine 

Relevant articles and documents

Direct Access to Primary Amines from Alkenes by Selective Metal-Free Hydroamination

Direct and selective synthesis of primary amines from easily available precursors is attractive yet challenging. Herein, we report the rapid synthesis of primary amines from alkenes via metal-free regioselective hydroamination at room temperature. Ammonium carbonate was used as ammonia surrogate for the first time, allowing for efficient conversion of terminal and internal alkenes into linear, α-branched, and α-tertiary primary amines under mild conditions. This method provides a straightforward and powerful approach to a wide spectrum of advanced, highly functionalized primary amines which are of particular interest in pharmaceutical chemistry and other areas.