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(R)-N-Fmoc-2-(5'-pentenyl)glycine is a chiral chemical compound derived from glycine, a simple amino acid, with a substituted pentenyl group. The "R" designation signifies its chirality, possessing a non-superposable mirror image. The Fmoc group serves as a protecting group in peptide synthesis, preventing undesired reactions during the assembly of peptide chains. (R)-N-Fmoc-2-(5'-pentenyl)glycine plays a role in the creation of peptide-based materials for applications in medical research, pharmaceutical development, and the study of protein structure and function.

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  • 1208226-88-3 Structure
  • Basic information

    1. Product Name: (R)-N-FMoc-2-(5'-pentenyl)glycine
    2. Synonyms: (R)-N-FMoc-2-(5'-pentenyl)glycine;(R)-N-Fmoc-2-(5'-hexyl)glycine;(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)oct-7-enoic acid
    3. CAS NO:1208226-88-3
    4. Molecular Formula: C22H23NO4
    5. Molecular Weight: 365.42232
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1208226-88-3.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 603.1±55.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.184±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: 2-8°C
    8. Solubility: N/A
    9. PKA: 3.90±0.21(Predicted)
    10. CAS DataBase Reference: (R)-N-FMoc-2-(5'-pentenyl)glycine(CAS DataBase Reference)
    11. NIST Chemistry Reference: (R)-N-FMoc-2-(5'-pentenyl)glycine(1208226-88-3)
    12. EPA Substance Registry System: (R)-N-FMoc-2-(5'-pentenyl)glycine(1208226-88-3)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1208226-88-3(Hazardous Substances Data)

1208226-88-3 Usage

Uses

Used in Pharmaceutical Development:
(R)-N-Fmoc-2-(5'-pentenyl)glycine is used as a building block in the synthesis of complex peptides for pharmaceutical development. Its chiral nature and the presence of the Fmoc protecting group allow for the controlled assembly of peptide chains with specific sequences, which can be crucial for the biological activity and therapeutic potential of the resulting peptides.
Used in Medical Research:
In the field of medical research, (R)-N-Fmoc-2-(5'-pentenyl)glycine is used as a component in the design and synthesis of novel peptide-based therapeutic agents. Its unique structural features enable the development of peptides with tailored properties, such as enhanced stability, selectivity, and bioavailability, which can improve their efficacy in treating various diseases and conditions.
Used in Protein Structure and Function Studies:
(R)-N-Fmoc-2-(5'-pentenyl)glycine is utilized as a key component in the study of protein structure and function. Its incorporation into peptide sequences allows researchers to investigate the effects of specific amino acid modifications on protein folding, stability, and interactions with other biomolecules. This knowledge can contribute to a better understanding of protein function and the development of new strategies for modulating protein activity in various biological processes.
Used in Organic Chemistry:
In the realm of organic chemistry, (R)-N-Fmoc-2-(5'-pentenyl)glycine serves as a versatile intermediate for the synthesis of various organic compounds. Its unique structural features, including the pentenyl group and the Fmoc protecting group, make it a valuable building block for the development of novel organic molecules with potential applications in various industries, such as materials science, pharmaceuticals, and agrochemicals.

Check Digit Verification of cas no

The CAS Registry Mumber 1208226-88-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,0,8,2,2 and 6 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1208226-88:
(9*1)+(8*2)+(7*0)+(6*8)+(5*2)+(4*2)+(3*6)+(2*8)+(1*8)=133
133 % 10 = 3
So 1208226-88-3 is a valid CAS Registry Number.

1208226-88-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name Fmoc-R6H-OH

1.2 Other means of identification

Product number -
Other names (2R)-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}oct-7-enoic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1208226-88-3 SDS

1208226-88-3Upstream product

1208226-88-3Downstream Products

1208226-88-3Relevant articles and documents

Novel potent apoA-I peptide mimetics that stimulate cholesterol efflux and pre-β particle formation in vitro

Ingenito, Raffaele,Burton, Charlotte,Langella, Annunziata,Chen, Xun,Zytko, Karolina,Pessi, Antonello,Wang, Jun,Bianchi, Elisabetta

supporting information; experimental part, p. 236 - 239 (2010/04/05)

Reverse cholesterol transport (RCT) is believed to be the primary mechanism by which HDL and its major protein apoA-I protect against atherosclerosis. Starting from the inactive 22-amino acid peptide representing the consensus sequence of the class A amphipathic helical repeats of apoA-I, we designed novel peptides able to mobilize cholesterol from macrophages in vitro, and to stimulate the formation of 'nascent HDL' particles, with potency comparable to the entire apoA-I protein.

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