- Palladium-Catalyzed Zinc-Amide-Mediated C-H Arylation of Fluoroarenes and Heteroarenes with Aryl Sulfides
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C-H arylation of polyfluoroarenes and heteroarenes with aryl sulfides proceeds smoothly with the aid of a palladium-N-heterocyclic carbene catalyst. A bulky zinc amide, TMPZnCl an effective base to generate the corresponding arylzinc species in situ. This arylation protocol is practically much easier to perform than our previous method, which necessitates preparation of the arylzinc reagents in advance from the corresponding aryl halides. Aryl sulfides that are prepared through sulfur-specific reactions, such as SNAr sulfanylation and extended Pummerer reactions, undergo this direct arylation, offering interesting transformations that are otherwise difficult to achieve with conventional halogen-based organic synthesis.
- Otsuka, Shinya,Yorimitsu, Hideki,Osuka, Atsuhiro
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supporting information
p. 14703 - 14707
(2015/10/20)
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- Nickel-catalyzed decarboxylative cross-coupling of perfluorobenzoates with aryl halides and sulfonates
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A Ni-catalyzed method for the coupling of perfluorobenzoates with aryl halides and pseudohalides is described. Aryl iodides, bromides, chlorides, triflates, and tosylates participate in these transformations to afford the products in good yields. Penta-, tetra-, and trifluorinated biaryl compounds are obtained using these newly developed Ni-catalyzed decarboxylative cross-coupling reactions.
- Sardzinski, Logan W.,Wertjes, William C.,Schnaith, Abigail M.,Kalyani, Dipannita
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supporting information
p. 1256 - 1259
(2015/05/20)
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- Pd-catalyzed decarboxylative cross coupling of potassium polyfluorobenzoates with aryl bromides, chlorides, and triflates
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Chemical Equetion Presentation Pd-catalyzed decarboxylative cross coupling of potassium polyfluorobenzoates with aryl bromides, chlorides, and triflates is achieved by using diglyme as the solvent. The reaction is useful for synthesis of polyfluorobiaryls
- Shang, Rui,Xu, Qing,Jiang, Yuan-Ye,Wang, Yan,Liu, Lei
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supporting information; experimental part
p. 1000 - 1003
(2010/06/16)
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