- PROCESS OF SYNTHESIZING AND PURIFYING (3R)-HYDROXYBUTYL (3R)-HYDROXYBUTANOATE
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A process for synthesizing (R)-3 -hy droxybutyl (R)-3 -hy droxybutanoate from ethyl (R)-3-hydroxybutanoate and (R)-l,3-butanediol, as well a process for synthesizing (R)-3-hy droxybutyl (R)-3-hy droxybutanoate from (R)-3-hydroxybutyric acid and (R)-l,3-butanediol. Also provided are processes for isolating (R)-3-hy droxybutyl (R)-3-hy droxybutanoate, including from a fermentation broth.
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Page/Page column 0537-0538
(2021/11/20)
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- Preparation method of (R)-3-hydroxybutyryl-(R)-3-hydroxybutyrate
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The invention discloses a preparation method of (R)-3-hydroxybutyryl-(R)-3-hydroxybutyrate. The preparation method comprises the following steps: (1) subjecting a compound (III) to reacting with paratoluensulfonyl chloride in a first solvent in the presence of alkali to obtain a compound (II); and (2) subjecting the compound (II) to reacting with (R)-3-hydroxybutyrate in a second solvent, or subjecting the compound (II) to reacting with (R)-3-hydroxybutyric acid in the presence of alkali. According to the invention, a route is simple, protection/deprotection reaction is avoided, the product can be obtained through two-step reaction from easily available raw materials, total yield is larger than or equal to 70%, and the purity of the product is larger than or equal to 95% without refining; and the method has the advantages of mild process conditions, no need for special equipment, low cost and suitability for industrial amplification, and related reagents and solvents are cheap and easy to obtain.
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Paragraph 0044-0048; 0049; 0052; 0053; 0055
(2021/07/01)
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- SYNTHESIS OF 3-HYDROXYBUTYRYL 3-HYDROXYBUTYRATE AND RELATED COMPOUNDS
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In various embodiments methods of preparing hydroxybutyryl 3-hydroxybutyrate and related compounds are provided along with methods of use thereof.
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Paragraph 0018; 0308; 0317; 0334-0336
(2021/04/02)
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- MULTIBIOTIC AGENTS AND METHODS OF USING THE SAME
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Multibiotic agents are disclosed. The multibiotic agents may contain two or more moieties linked through bonds cleavable in vivo. The bonds cleavable in vivo can be ester bonds, amide bonds, azo bonds, glycosidic bonds, carbonate linkers, or carbamate linkers. The moieties can be alcohol cores, amine cores, and/or acyls. Also disclosed are compositions containing multibiotic agents and methods of using the multibiotic agents.
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Page/Page column 153
(2019/01/06)
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- PROCESS FOR PRODUCING (R)-3-HYDROXYBUTYL (R)-3-HYDROXYBUTYRATE
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A process for the production of (R)-3-hydroxybutyl (R)-3-hydroxybutyrate comprising: i) contacting poly-(R)-3-hydroxybutyrate with an alcohol to transesterify the poly-(R)-3-hydroxybutyrate under transesterification conditions to produce an ester of (R)-3-hydroxybutyrate and the alcohol; ii) separating the product of step i) into a first and second portion and reducing the first portion of the (R) 3-hydroxybutyrate ester to form (R)-1,3-butanediol; and iii) contacting under transesterification conditions the (R)-1,3-butanediol from step ii) with the second portion of the transesterified ester to produce (R)-3-hydroxybutyl-(R)-hydroxybutanoate.
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Page/Page column 7; 8
(2014/09/29)
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- HYDROXYBUTYRATE ESTER AND MEDICAL USE THEREOF
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A compound which is 3-hydroxybutyl 3-hydroxybutyrate enantiomerically enriched with respect to (3R)-hydroxybutyl (3R)-hydroxybutyrate of formula (I) is an effective and palatable precursor to the ketone body (3R)-hydroxybutyrate and may therefore be used to treat a condition which is caused by, exacerbated by or associated with elevated plasma levels of free fatty acids in a human or animal subject, for instance a condition where weight loss or weight gain is implicated, or to promote alertness or improve cognitive function, or to treat, prevent or reduce the effects of neurodegeneration, free radical toxicity, hypoxic conditions or hyperglycaemia.
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Page/Page column 5
(2011/10/12)
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- HYDROXYBUTYRATE ESTER AND MEDICAL USE THEREOF
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A compound which is 3-hydroxybutyl 3-hydroxybutyrate enantiomerically enriched with respect to (3Λ)?hydroxybutyl (3i?)-hydroxybutyrate of formula (I): is an effective and palatable precursor to the ketone body (3Λ)-hydroxybutyrate and may therefore be used to treat a condition which is caused by, exacerbated by or associated with elevated plasma levels of free fatty acids in a human or animal subject, for instance a condition where weight loss or weight gain is implicated, or to promote alertness or improve cognitive function, or to treat, prevent or reduce the effects of, neuro degeneration, free radical toxicity, hypoxic conditions or hyperglycaemia.
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Page/Page column 12
(2010/04/03)
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