- Preparation method of 7H-pyrrolo [2, 3-d] pyrimidine compound
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The invention discloses a preparation method of a 7H-pyrrolo [2, 3-d] pyrimidine compound. The full name of the 7H-pyrrolo [2, 3-d] pyrimidine compound is trans-N-methyl-4-(methyl-7H-pyrrolo [2, 3-d]pyrimidine-4-yl amino) cyclohexylmethanesulfonamide male
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- Preparation method of olatinib maleate
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The invention discloses a preparation method of olatinib maleate. Trans-4-[(tert-butyloxycarbonyl) amino] cyclohexanecarboxylic acid and 4-chloro-7toluenesulfonyl-7Hpyrrolo-[2, 3-d] pyrimidine are used as starting materials, and the olatinib maleate is ob
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- SOLID STATE FORMS OF OCLACITINIB MALEATE
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The present invention relates to solid state forms of oclacitinib maleate and methods for the preparation of the solid state forms of oclacitinib maleate. The solid state forms of oclacitinib maleate of the present invention include amorphous oclacitinib maleate, crystalline tetramethyl urea solvate form of oclacitinib maleate, crystalline monohydrate form of oclacitinib maleate and crystalline form of oclacitinib maleate (form B).
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Page/Page column 13-14
(2020/08/22)
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- Novel preparation method for oclacitinib
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The invention specially provides a novel preparation method for oclacitinib, belonging to the field of pharmaceutical synthesis. The invention provides a compound with a structure as shown in a formula V which is described in the specification for implementation of the method. The compound can be used for synthesizing oclacitinib and maleate thereof. The preparation method for oclacitinib maleate has the advantages of few operation steps, no need for column chromatography and good industrial operability, and thus, the preparation method has good application prospects.
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- PROCESS FOR PREPARING 7H-PYRROLO[2,3-D]PYRIMIDINE COMPOUNDS
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Described herein are improved processes for the preparation of the 7H-pyrrolo[2,3-d]pyrimidine compound, N-methyl-1-{trans-4-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclohexyl}-methanesulfonamide, intermediates thereof, and veterinary acceptable salts thereof.
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- PYRROLO[2,3-D]PYRIMIDINE COMPOUNDS
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Described herein is pyrrolo{2,3-d}pyrimidine compounds, their use as Janus Kinase (JAK) inhibitors, pharmaceutical compositions containing this compounds, and methods for the preparation of these compounds.
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Page/Page column 22
(2010/04/03)
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