Synthesis of the Novel ?-(Benzyloxymethyl)-Protected Histidine Analogue of Statine. Inhibition of Penicillopepsin by Pepstatin-Derived Peptides Containing Different Statine Side-Chain Derivatives
The synthesis of aspartic proteinase inhibitors derived from a new histidine side-chain analogue of statine (Sta), (3S,4S)-4-amino-3-hydroxy-5-(imidazol-4-yl)pentanoic acid (HiSta, 20), is reported.Boc-HiSta(BOM)-OMe (7) was prepared in 16percent overall
Maibaum, Juergen,Rich, Daniel H.
p. 1571 - 1576
(2007/10/02)
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