Synthesis of analogs of the radiation mitigator JP4-039 and visualization of BODIPY derivatives in mitochondria
JP4-039 is a lead structure in a series of nitroxide conjugates that are capable of accumulating in mitochondria and scavenging reactive oxygen species (ROS). To explore structure-activity relationships (SAR), new analogs with variable nitroxide moieties were prepared. Furthermore, fluorophore-tagged analogs were synthesized and provided the opportunity for visualization in mitochondria. All analogs were tested for radioprotective and radiomitigative effects in 32Dcl3 cells.
Frantz, Marie-Céline,Skoda, Erin M.,Sacher, Joshua R.,Epperly, Michael W.,Goff, Julie P.,Greenberger, Joel S.,Wipf, Peter
p. 4147 - 4153
(2013/07/19)
2-ALKYLBENZOXAZOLE CARBOXAMIDES AS 5HT3 MODULATORS
Compounds of formulae I and II: are disclosed as 5-HT3 inhibitors. Those compounds are useful in treating CINV, IBS-D and other diseases and conditions.
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Page/Page column 14
(2008/12/08)
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