1208538-52-6

Basic information

• Product Name: 4-Bromo-2-(methylsulfonyl)pyrimidine
• Synonyms: 4-Bromo-2-(methylsulfonyl)pyrimidine;4-Bromo-2-(methylsulfonyl)
• CAS NO: 1208538-52-6
• Molecular Formula: C5H5BrN2O2S
• Molecular Weight: 237
• Product Categories: Heterocycle-Pyrimidine series
• Mol File: 1208538-52-6.mol

Chemical Properties

• Melting Point: 111-112 °C
• Boiling Point: 393.716 °C at 760 mmHg
• Flash Point: 191.913 °C
• Appearance: White Solid
• Density: 1.771 g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -4.97±0.20(Predicted)
• CAS DataBase Reference: 4-Bromo-2-(methylsulfonyl)pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Bromo-2-(methylsulfonyl)pyrimidine(1208538-52-6)
• EPA Substance Registry System: 4-Bromo-2-(methylsulfonyl)pyrimidine(1208538-52-6)

Safety Data

• Hazardous Substances Data: 1208538-52-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-Bromo-2-(methylsulfonyl)pyrimidine is used as a synthetic intermediate for the development of new drugs, leveraging its ability to form heterocyclic compounds which are often found in biologically active molecules.
Used in Agrochemical Industry:
In the agrochemical sector, 4-Bromo-2-(methylsulfonyl)pyrimidine is utilized as a reagent in the synthesis of compounds that contribute to crop protection and enhancement of agricultural yields.
Used in Organic Synthesis:
4-Bromo-2-(methylsulfonyl)pyrimidine serves as a versatile building block in organic synthesis, enabling the creation of a wide array of heterocyclic compounds that are integral to various chemical and pharmaceutical applications.
Used as a Research Reagent:
In academic and research settings, 4-Bromo-2-(methylsulfonyl)pyrimidine is employed as a reagent to explore new methods and pathways in chemical synthesis, potentially leading to innovative discoveries in material and pharmaceutical sciences.

Upstream product

• 49844-90-8 4-Chloro-2-methylthiopyrimidine 
• 959236-97-6 4-bromo-2-methylsulfanylpyrimidine 
• 5751-20-2 2-Methylthiouracil 

Relevant articles and documents

INHIBITORS OF WDR5 PROTEIN-PROTEIN BINDING

The present application is directed to compounds of Formula I: compounds comprising these compounds and their uses, for example as medicaments for the treatment of diseases, disorders or conditions mediated or treatable by inhibition of binding between WDR5 protein and its binding partners.

Structure–Activity Relationships of 2-Sufonylpyrimidines as Quorum-Sensing Inhibitors to Tackle Biofilm Formation and eDNA Release of Pseudomonas aeruginosa

Drug-resistant Pseudomonas aeruginosa (PA) strains are on the rise, making treatment with current antibiotics ineffective. Hence, circumventing resistance or restoring the activity of antibiotics by novel approaches is of high demand. Targeting the Pseudomonas quinolone signal quorum sensing (PQS-QS) system is an intriguing strategy to abolish PA pathogenicity without affecting the viability of the pathogen. Herein we report the structure–activity relationships of 2-sulfonylpyrimidines, which were previously identified as dual-target inhibitors of the PQS receptor PqsR and the PQS synthase PqsD. The SAR elucidation was guided by a combined approach using ligand efficiency and ligand lipophilicity efficiency to select the most promising compounds. In addition, the most effective inhibitors were rationally modified by the guidance of QSAR using Hansch analyses. Finally, these inhibitors showed the capacity to decrease biofilm mass and extracellular DNA, which are important determinants for antibiotic resistance.

Synthesis of cytimidine through a one-pot copper-mediated amidation cascade

A concise synthesis of cytimidine was developed utilizing tandem Cu-mediated N-aryl amidations followed by global deprotection. This sequence exploits a regioselective coupling of an iodobenzamide with a halopyrimidine that allows the union of three fragments in a single synthetic manipulation and will permit the efficient and rapid diversification of the cytimidine core.