Design and Synthesis of Highly Specific and Selective Enkephalin Analog Containing S-Npys-Cysteine for &δ Opioid Receptors
Enkephalin analogs containing S-(3-nitro-2-pyridinesulfenyl)cysteine at positions of 1, 5, or 6 were synthesized for searching possible thiol groups in the opioid receptors.In the radio-ligand receptor assay and biological assays, 2, Leu5>enkephalyl-Cys(Npys)6 exhibited a very high affinity and selectivity for δ over μ receptors, and its covalent attachment to δ receptors through the disulfide bonding was evidenced.
Get Best Price for120866-04-8(R)-2-[(S)-2-(2-{(R)-2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-propionylamino}-acetylamino)-3-phenyl-propionylamino]-3-(3-nitro-pyridin-2-yldisulfanyl)-propionic acid