120893-72-3Relevant articles and documents
Synthesis and biological evaluation of a novel 99mTc labeled 2-nitroimidazole derivative as a potential agent for imaging tumor hypoxia
Joyard, Yoann,Joncour, Vadim Le,Castel, Hélène,Diouf, Chérif Bounana,Bischoff, Laurent,Papamica?l, Cyril,Levacher, Vincent,Vera, Pierre,Bohn, Pierre
, p. 3704 - 3708 (2013)
Tumor hypoxia plays a major role in reducing the efficacy of therapeutic modalities like chemotherapy and radiation therapy in combating cancer. In order to target hypoxic tissues, a tripeptide ligand having a 2-nitroimidazole moiety, as a bioreductive species, was synthesized. The latter was radiolabeled with 99mTc for imaging hypoxic regions of tumors and was characterized by means of its rhenium analogue. The biodistribution and scintigraphic image of the corresponding 99mTc-complex showed accumulation in tumor and these results suggest that it could be a marker for imaging tumor hypoxia.
Binding of a hemoregulatory tetrapeptide by a bis-guanidinium crown ether
Sp?th, Andreas,K?nig, Burkhard
supporting information; experimental part, p. 6019 - 6025 (2010/10/02)
A synthetic receptor for the molecular recognition of a tetrapeptide in aqueous buffer was obtained by combining a luminescent crown ether with two pyrrole-guanidinium moieties. The compound interacts with ammonium carboxylates of complementary geometry a
