120940-43-4

Basic information

• Product Name: 1-METHYL-1-[2-NITRO-4-(TRIFLUOROMETHYL)PHENYL]HYDRAZINE
• Synonyms: 1-METHYL-1-[2-NITRO-4-(TRIFLUOROMETHYL)PHENYL]HYDRAZINE;N-METHYL-N-[2-NITRO-4-(TRIFLUOROMETHYL)PHENYL]HYDRAZINE;Methylnitrotrifluoromethylphenylhydrazine;N-Methyl-N-[2-nitro-4-(trifluoromethyl)phenyl]hydrazine 97%;N-Methyl-N-[2-nitro-4-(trifluoromethyl)phenyl]hydrazine97%;N-Methyl-N-[2-nitro-4-(trifluoromethyl)phenyl];1-Methyl-1-2-nitro-4-(trifluoromethyl)phenylühydrazine, 97%
• CAS NO: 120940-43-4
• Molecular Formula: C₈H₈F₃N₃O₂
• Molecular Weight: 235.16
• Mol File: 120940-43-4.mol

Chemical Properties

• Melting Point: 68 °C
• Boiling Point: 68-70
• Flash Point: 135.6°C
• Appearance: /
• Density: 1.47g/cm³
• Vapor Pressure: 0.00111mmHg at 25°C
• Refractive Index: 1.55
• Storage Temp.: 2-8°C
• PKA: 3.06±0.35(Predicted)
• CAS DataBase Reference: 1-METHYL-1-[2-NITRO-4-(TRIFLUOROMETHYL)PHENYL]HYDRAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-METHYL-1-[2-NITRO-4-(TRIFLUOROMETHYL)PHENYL]HYDRAZINE(120940-43-4)
• EPA Substance Registry System: 1-METHYL-1-[2-NITRO-4-(TRIFLUOROMETHYL)PHENYL]HYDRAZINE(120940-43-4)

Safety Data

• Hazard Codes: Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37
• Hazardous Substances Data: 120940-43-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1-METHYL-1-[2-NITRO-4-(TRIFLUOROMETHYL)PHENYL]HYDRAZINE is used as an intermediate in the synthesis of various pharmaceuticals. Its unique structure allows for the development of new drugs with potential therapeutic effects.
Used in Agrochemical Industry:
1-METHYL-1-[2-NITRO-4-(TRIFLUOROMETHYL)PHENYL]HYDRAZINE is used in the synthesis of agrochemicals, specifically as a precursor for the development of new pesticides. Its properties can contribute to the creation of effective pest control solutions.
Used in Pesticide Development:
1-METHYL-1-[2-NITRO-4-(TRIFLUOROMETHYL)PHENYL]HYDRAZINE has been studied for its potential use as a pesticide. Its chemical structure may offer new possibilities for pest control, enhancing agricultural productivity and crop protection.
However, it is important to note that 1-METHYL-1-[2-NITRO-4-(TRIFLUOROMETHYL)PHENYL]HYDRAZINE has the potential to act as a mutagenic and genotoxic agent. Therefore, precautions should be taken when handling this compound to minimize risks to human health and the environment.

InChI:InChI=1/C8H8F3N3O2/c1-13(12)6-3-2-5(8(9,10)11)4-7(6)14(15)16/h2-4H,12H2,1H3

Upstream product

• 121-17-5 2-chloro-3-nitro-5-trifluoromethylbenzene 
• 60-34-4 methylhydrazine 
• 367-86-2 1-fluoro-2-nitro-4-trifluoromethyl-benzene 

Downstream Products

• 120914-43-4 N-methyl-N-(2-nitro-4-phenyl)-N'N'-phthaloylhydrazine 
• 218156-52-6 C₁₀H₇F₆N₃O₃ 

Relevant articles and documents

Synthesis of 3-aryl substituted benzo[1,2,5]triazepin-4-ones via intramolecular imine formation

3-Aryl substituted benzo[1,2,5]triazepin-4-ones and their pyrido counterparts have been synthesized in five steps from commercially available starting materials. The key step involves base-induced cleavage of trifluoroacetyl-protected hydrazine intermedia

Synthesis and Thermal Reactions of 1,2-Dihydro-1,2,4-benzotriazines

The 1,2-dimethyl-1,2,4-benzotriazines (7),(8), and (9) were prepared by acid-catalysed cyclisation of the 2-aminophenylhydrazine derivatives derived from (12), (13), and (14) respectively.Compounds (7) and(9) undergo a thermal elimination to fully aromatic benzotriazines.However, the 2-acyl derivative (18) rearranges to the thermodynamically more stable 4-acyl compound (21).In the presence of traces of water, a ring contraction to benzimidazoles is a competing reaction.For (18) the nitrogen fragment is retained in the benzamide (22).A mechanism for the ring contraction has been suggested in which initial hydration of the imine bond gives 1,2,3,4-tetrahydrobenzotriazines which ring-open, then re-cyclise to benzimidazoles.The benzimidazophthalazine (23) was shown not to be an intermediate in the water-mediated ring contraction of (18).