120966-60-1Relevant academic research and scientific papers
α-heterosubstituted aldehydes in organic synthesis. Enantioselective approaches to new analogues of mevinic acids
Enders, Dieter,Burkamp, Frank
, p. 975 - 1006 (2007/10/03)
Various aldol approaches towards the asymmetric synthesis of the lactone moiety of HMG-CoA-reductase inhibitors are described. Auxiliary controlled as well as catalytic aldol reactions resulted only in modest to low selectivities, whereas 1,2-additions to readily available highly enantiomerically enriched α-heterosubstituted aldehydes yielded δ-hydroxy-β-ketoesters with a high degree of diastereocontrol and in good chemical yields. The novel mevinic acid analogues could then be obtained by syn-reduction of the addition products.
Stereoselective Syntheses of erythro- and threo-β-Amino Alcohol Derivatives via Hetero-Diels-Alder Reactions
Midland, M.Mark,Afonso, Maria M.
, p. 4368 - 4371 (2007/10/02)
The reaction of 1,3-dimethoxy-1-butadiene with a variety of N-protected α-amino aldehydes under the influence of Lewis acid has been studied.The reaction provides an α,β-unsaturated lactone that is useful in further transformations.Wh
