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CAS

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1210004-12-8

JZL 195 is a potent dual inhibitor of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL), enzymes responsible for the hydrolysis of endocannabinoids arachidonoyl ethanolamide (AEA) and 2-arachidonoylglycerol (2-AG), respectively. It exhibits high selectivity and efficacy with IC50 values of 2 and 4 nM for FAAH and MAGL, respectively. JZL 195 does not inhibit other brain serine hydrolases and displays time-dependent inhibition of FAAH and MAGL in vivo, consistent with a covalent mechanism of action. By inhibiting these enzymes, JZL 195 increases brain levels of AEA and 2-AG, leading to antinociceptive, cataleptic, and hypomotility effects similar to those produced by direct CB1 agonists.

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  • 1210004-12-8 Structure

  • Basic information

    1. Product Name: JZL 195
    2. Synonyms: JZL 195;4-nitrophenyl 4-(3-phenoxybenzyl)piperazine-1-carboxylate;4-[(3-Phenoxyphenyl)methyl]-1-piperazinecarboxylic acid 4-nitrophenyl ester
    3. CAS NO:1210004-12-8
    4. Molecular Formula: C24H23N3O5
    5. Molecular Weight: 433.45652
    6. EINECS: N/A
    7. Product Categories: API;Inhibitors
    8. Mol File: 1210004-12-8.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 581.8±50.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: white to beige/
    5. Density: 1.303±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: ?20°C
    8. Solubility: DMSO: ≥5mg/mL at warmed
    9. PKA: 6.13±0.10(Predicted)
    10. CAS DataBase Reference: JZL 195(CAS DataBase Reference)
    11. NIST Chemistry Reference: JZL 195(1210004-12-8)
    12. EPA Substance Registry System: JZL 195(1210004-12-8)

  • Safety Data

    1. Hazard Codes: N
    2. Statements: 50
    3. Safety Statements: 61
    4. RIDADR: UN 3077 9 / PGIII
    5. WGK Germany: 3
    6. RTECS:
    7. HazardClass: N/A
    8. PackingGroup: N/A
    9. Hazardous Substances Data: 1210004-12-8(Hazardous Substances Data)

1210004-12-8 Usage

Uses

Used in Pharmaceutical Industry:
JZL 195 is used as a dual FAAH/MAGL inhibitor for its potential therapeutic applications in treating pain and inflammation. Its ability to augment brain levels of AEA and 2-AG makes it a promising candidate for the development of novel analgesic and anti-inflammatory drugs.
Used in Neurological Research:
JZL 195 is used as a research tool to study the role of endocannabinoids in various neurological processes and disorders. Its selective inhibition of FAAH and MAGL allows for a better understanding of the endocannabinoid system's involvement in pain, anxiety, and other neurological conditions.
Used in Drug Development:
JZL 195 is used as a lead compound in the development of new drugs targeting the endocannabinoid system. Its high potency and selectivity make it an attractive starting point for the design of more effective and safer therapeutic agents for various medical conditions.

Check Digit Verification of cas no

The CAS Registry Mumber 1210004-12-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,1,0,0,0 and 4 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1210004-12:
(9*1)+(8*2)+(7*1)+(6*0)+(5*0)+(4*0)+(3*4)+(2*1)+(1*2)=48
48 % 10 = 8
So 1210004-12-8 is a valid CAS Registry Number.

1210004-12-8 Well-known Company Product Price

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  • Sigma

  • (SML0257)  JZL195  ≥98% (HPLC)

  • 1210004-12-8

  • SML0257-5MG

  • 1,041.30CNY

  • Detail

  • Sigma

  • (SML0257)  JZL195  ≥98% (HPLC)

  • 1210004-12-8

  • SML0257-25MG

  • 4,201.47CNY

  • Detail

1210004-12-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name JZL 195

1.2 Other means of identification

Product number -
Other names 4-[(3-Phenoxyphenyl)methyl]-1-piperazinecarboxylic acid 4-nitrophenyl ester

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1210004-12-8 SDS

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