- Experimental dipole moments of some 1-nitro or 1-amino substituted 9-acridinones and/or 9-acridine-thiones as solutes in dioxane, measured at various temperatures
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Theoretical dipole moments of these compounds have been calculated using CNDO/2 calculations and vectorial incremental addition. According to the comparison between experimental and theoretical dipole moments as well as the values of 13C(9) chemical shifts, some structural features have been portrayed. For example, geometry of the C(1)-substituent and spatial orientation of the N(10)-R bond are given whilst the slight folding of the molecules along a fictitious N(10)-C(9) axis is estimated. Moreover, the existence of intramolecular hydrogen bonding is discussed. In addition, it is shown that electromeric interactions between the amino groups and the oxygen or sulfur atoms considerably contribute to the dielectric and spectroscopic properties of the compounds investigated.
- Ngadi,Brouant,Galy,Galy,Soyfer,Barbe
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- Some new 1-nitro acridine derivatives as antimicrobial agents
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Some new 1-nitro acridine derivatives were prepared and characterized. These compounds were screened for evaluating their antimicrobial properties against Gram+ bacteria, Gram- bacteria, and mycobacteria as well as fungi. With reference to the results obtained, 1-nitro-4-aminoethylamine-9-alkylthioacridines must be considered as promising lead molecules.
- Ngadi,Galy,Galy,Barbe,Cremieux,Chevalier,Sharples
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- Synthesis and antiparasitic activity of new 1-nitro, 1-amino and 1-acetamido 9-acridinones
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The synthesis of 1-amino-10-alkyl-9-acridinones 4 and 5 and of homologous 9-thio-acridinones 7 and 8 are described. Similarly, the synthesis of 1-nitro-4-(2'-aminoethylamino)-9-acridinones 13 and 15, is described. Compound 4 was used as starting material for the preparation of 10-alkyl-9-acridinone dimers 6, bridged with an α,ω-diamido chain. Compound 15 was selected for biological investigations on pathogenic parasite strains, and a promising antiamoebic activity could be shown.
- Ngadi,Bsiri,Mahamoud,Galy,Galy,Soyfer,Barbe,Placidi,Rodriguez-Santiago,Mesa-Valle,Lombardo,Mascaro,Osuna
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p. 480 - 483
(2007/10/02)
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